Central nervous system (CNS) disorders especially neurodegenerative disorders are the major challenge for public health and demand the great attention of researchers to protect people against them. In past few decades, different treatment strategies have been adopted, but their therapeutic efficacy are not enough and have only shown partial mitigation of symptoms. Blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BSCFB) guard the CNS from harmful substances and pose as the major challenges in delivering drugs into CNS for treatment of CNS complications such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), stroke, epilepsy, brain tumors, multiple sclerosis (MS), and encephalitis, etc. Nanotechnology has come out as an exciting and promising new platform of treating neurological disorders and has shown great potential to overcome problems related to the conventional treatment approaches. Molecules can be nanoengineered to carry out multiple specific functions such as to cross the BBB, target specific cell or signaling pathway, respond to endogenous stimuli, and act as a vehicle for gene delivery, support nerve regeneration and cell survival. In present review, the role of nanocarrier systems such as liposomes, micelles, solid lipid nanoparticles (SLNPs), dendrimers, and nanoemulsions for delivery of various neurotherapeutic agents has been discussed, besides this, their mechanism of action, and nanoformulation of different neuroprotective agents like curcumin, edaravone, nerve growth factors in CNS disorders like Alzheimer’s, Parkinsonism, epilepsy, stroke, and brain tumors has been reviewed.

中文翻译：

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纳米技术：一种有前景的神经保护药物递送方法

中枢神经系统 (CNS) 疾病尤其是神经退行性疾病是公共卫生的主要挑战，需要研究人员高度重视以保护人们免受这些疾病的侵害。在过去的几十年里，采取了不同的治疗策略，但它们的治疗效果还不够，只能部分缓解症状。血脑屏障 (BBB) 和血脑脊液屏障 (BSCFB) 保护中枢神经系统免受有害物质的侵害，并成为将药物输送到中枢神经系统以治疗中枢神经系统并发症如阿尔茨海默病 (AD)、帕金森病 (PD) 的主要挑战)、亨廷顿病 (HD)、中风、癫痫、脑肿瘤、多发性硬化症 (MS) 和脑炎等。纳米技术已成为治疗神经系统疾病的一个令人兴奋和有前途的新平台，并显示出克服与传统治疗方法相关的问题的巨大潜力。分子可以通过纳米工程实现多种特定功能，例如穿过 BBB、靶向特定细胞或信号通路、响应内源性刺激、作为基因传递的载体、支持神经再生和细胞存活。在本综述中，讨论了脂质体、胶束、固体脂质纳米粒子 (SLNP)、树枝状聚合物和纳米乳剂等纳米载体系统在递送各种神经治疗剂中的作用，此外还讨论了它们的作用机制和不同神经保护剂的纳米制剂如姜黄素、依达拉奉、中枢神经系统疾病（如阿尔茨海默病）中的神经生长因子，