Intracerebral hemorrhage (ICH) is associated with high morbidity and mortality rates. Currently, there is no promising treatment that improves prognosis significantly. While a thorough investigation of the pathological process within the primary site of injury in the brain has been conducted by the research field, the focus was mainly on gray matter injury, which partly accounted for the failure of discovery of clinically efficacious treatments. It is not until recent years that white matter (WM) injury in the brain after subcortical ICH was examined. As WM tracts form networks between different regions, damage to fibers should impair brain connectivity, resulting in functional impairment. Although WM changes have been demonstrated in the brain after ICH, alterations distant from the initial injury site down in the spinal cord are unclear. This longitudinal study, for the first time, revealed prolonged morphological changes of the contralesional dorsal corticospinal tract (CST) in the spinal cord 5 weeks after experimental ICH in mice by confocal microscopy and transmission electron microscopy, implying that the structural integrity of the CST was compromised extensively after ICH. Given the important role of CST in motor function, future translational studies targeting motor recovery should delineate the treatment effects on CST integrity.

中文翻译：

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小鼠右侧纹状体脑出血后颈脊髓内皮质脊髓束的长期形态学变化

脑出血 (ICH) 与高发病率和死亡率相关。目前，没有显着改善预后的有希望的治疗方法。虽然研究领域已经对大脑原发部位的病理过程进行了彻底的调查，但重点主要是灰质损伤，这在一定程度上解释了临床有效治疗方法的失败。直到最近几年才检查了皮层下 ICH 后大脑中的白质 (WM) 损伤。由于 WM 束在不同区域之间形成网络，对纤维的损伤会损害大脑的连通性，从而导致功能障碍。尽管 ICH 后大脑中的 WM 变化已得到证实，但远离脊髓中初始损伤部位的变化尚不清楚。这项纵向研究首次通过共聚焦显微镜和透射电子显微镜揭示了小鼠实验性 ICH 后 5 周脊髓中对侧皮质脊髓束 (CST) 的长期形态变化，这意味着 CST 的结构完整性是在 ICH 后受到广泛的损害。鉴于 CST 在运动功能中的重要作用，未来针对运动恢复的转化研究应该描述治疗对 CST 完整性的影响。