Sex, comprising biological and gender-related distinctions, is a known risk factor for alcohol use disorders. Moreover, sensation seeking, impulsivity, and aggression have been found to predict binge drinking and to reflect behavioral disinhibition. We tested effects of these disinhibited traits on binging during intravenous alcohol self-administration (ivASA), a method that eliminates sex differences in the pharmacokinetics of alcohol. Eighty-five German social drinkers (49 men) completed 3 questionnaires assessing sensation seeking, impulsivity, and aggression, as well as an ivASA session at ages 18-19. Sixty-five of them were retested at ages 21-22. Participants reported real-life drinking problems and the number of binge days in the 45 days preceding lab testing. Analyses employed continuous data and median splits to examine associations between disinhibited traits and the portion of women and men in the sample who achieved a breath alcohol concentration of 80 mg% during ivASA ("binge fraction"). At ages 18-19, and only if scoring low on sensation seeking, impulsivity, or aggression, women had significantly lower binge fractions during ivASA than men. Further, low compared to high impulsivity or aggression predicted lower binge fractions in women but not in men. Neither first- nor second-wave disinhibited traits significantly predicted binge fractions at ages 21-22. We perceive that personality traits reflecting behavioral disinhibition might be a strong indicator of drinking problems, specifically among young women. Targeted brief interventions might therefore be used in educational or clinical settings to inform such women about their increased risk and the potential health and behavioral problems associated with binge drinking. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

中文翻译：

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感觉寻求、冲动和攻击性对青少年实验室狂欢的中度性影响。

性别，包括生物学和性别相关的区别，是酒精使用障碍的一个已知风险因素。此外，已经发现感觉寻求、冲动和攻击性可以预测酗酒并反映行为去抑制。我们测试了这些去抑制性状对静脉内酒精自我给药 (ivASA) 期间暴饮暴食的影响，这是一种消除酒精药代动力学性别差异的方法。85 名德国社交饮酒者（49 名男性）完成了 3 份评估感觉寻求、冲动和攻击性的问卷，以及 18-19 岁的 ivASA 会议。其中 65 人在 21-22 岁时接受了重新测试。参与者报告了现实生活中的饮酒问题和实验室测试前 45 天的暴饮暴食天数。分析采用连续数据和中位数分割来检查去抑制性状与样本中在 ivASA 期间达到 80 mg% 呼吸酒精浓度的女性和男性部分之间的关​​联（“狂欢分数”）。在 18-19 岁时，只有在感觉寻求、冲动或攻击性方面得分较低时，女性在 ivASA 期间的暴食分数显着低于男性。此外，与高冲动或攻击性相比，低与高相比预测女性的暴饮率较低​​，但男性则不然。第一波和第二波去抑制性状都不能显着预测 21-22 岁的暴食分数。我们认为反映行为去抑制的人格特征可能是饮酒问题的一个强有力的指标，特别是在年轻女性中。因此，可以在教育或临床环境中使用有针对性的简短干预措施，以告知这些女性他们增加的风险以及与酗酒相关的潜在健康和行为问题。（PsycInfo 数据库记录 (c) 2020 APA，保留所有权利）。