Vascular remodeling is the adaptive response to various physiological and pathophysiological alterations that are closely related to aging and vascular diseases. Understanding the mechanistic regulation of vascular remodeling may be favorable for discovering potential therapeutic targets and strategies. The extracellular matrix (ECM), including matrix proteins and their degradative metalloproteases, serves as the main component of the microenvironment and exhibits dynamic changes during vascular remodeling. This process involves mainly the altered composition of matrix proteins, metalloprotease-mediated degradation, posttranslational modification of ECM proteins, and altered topographical features of the ECM. To date, adequate studies have demonstrated that ECM dynamics also play a critical role in vascular remodeling in various diseases. Here, we review these related studies, summarize how ECM dynamics control vascular remodeling, and further indicate potential diagnostic biomarkers and therapeutic targets in the ECM for corresponding vascular diseases.

中文翻译：

---

血管重塑中的细胞外基质动力学。

血管重塑是对与衰老和血管疾病密切相关的各种生理和病理生理改变的适应性反应。了解血管重塑的机制调控可能有利于发现潜在的治疗靶点和策略。细胞外基质（ECM），包括基质蛋白及其降解金属蛋白酶，是微环境的主要组成部分，并在血管重塑过程中表现出动态变化。该过程主要涉及基质蛋白组成的改变、金属蛋白酶介导的降解、ECM 蛋白的翻译后修饰以及 ECM 的地形特征改变。迄今为止，充分的研究表明，ECM 动力学也在各种疾病的血管重塑中发挥着关键作用。这里，