CD8+ T cells are increased in the subventricular zone with physiological and pathological aging.,Aging Cell

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CD8+ T cells are increased in the subventricular zone with physiological and pathological aging.
Aging Cell ( IF 8.0 ) Pub Date : 2020-08-01 , DOI: 10.1111/acel.13198
Manuel Moreno-Valladares _{1,

2} , Leire Moreno-Cugnon ₁ , Tulio Mateo Silva ₂ , Juan Pablo Garcés ₂ , Ander Saenz-Antoñanzas ₁ , María Álvarez-Satta ₁ , Ander Matheu _{1,

3,

4}

Affiliation

Age‐related cognitive decline and neurodegenerative diseases are associated with less functional neurogenic niches. It has been recently shown that aged subventricular zone (SVZ) suffers an infiltration of T cells, which affects neural stem cell activity in mice. Whether this occurs in human neurogenic niches or to which extent T‐cell infiltration is also taking place in neurodegenerative diseases remains unknown. In this work, we studied the presence of T cells in both human neurogenic niches in young and old individuals. There was a significant increase in the number of CD3⁺ and CD8⁺ T cells in the SVZ of elderly individuals, which was not detected in the dentate gyrus. Moreover, we also found CD3⁺ and CD8⁺ T cells in the SVZ of individuals with neurodegenerative diseases. However, T‐cell count was similar when compared non‐neuropathological elderly with disease diagnosed patients. Our study reveals the infiltration of T cells in old human brains, particularly in the SVZ under non‐pathological conditions and also in neurodegenerative contexts.

中文翻译：

CD8+ T 细胞在脑室下区随着生理和病理老化而增加。

与年龄相关的认知能力下降和神经退行性疾病与功能较少的神经源性生态位有关。最近的研究表明，老年脑室下区 (SVZ) 会出现 T 细胞浸润，这会影响小鼠的神经干细胞活性。这是否发生在人类神经源性壁龛中，或者在何种程度上 T 细胞浸润也在神经退行性疾病中发生仍然未知。在这项工作中，我们研究了年轻人和老年人的人类神经源性生态位中 T 细胞的存在。老年个体SVZ中CD3 ⁺和CD8 ⁺ T细胞数量显着增加，在齿状回中未检测到。此外，我们还发现 CD3 ⁺和 CD8 ⁺患有神经退行性疾病的个体 SVZ 中的 T 细胞。然而，当将非神经病理学老年人与疾病诊断患者进行比较时，T 细胞计数相似。我们的研究揭示了 T 细胞在老年人大脑中的浸润，特别是在非病理条件下的 SVZ 以及神经退行性环境中。

更新日期：2020-09-24

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