Outcome measures from experimental traumatic brain injury in male rats vary with the complete temporal biomechanical profile of the injury event.,Journal of Neuroscience Research

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Outcome measures from experimental traumatic brain injury in male rats vary with the complete temporal biomechanical profile of the injury event.
Journal of Neuroscience Research ( IF 2.9 ) Pub Date : 2020-08-02 , DOI: 10.1002/jnr.24670
Radia Abdul-Wahab _{1,

2} , Mathew T Long ₁ , Rafael Ordaz ₂ , Bruce G Lyeth ₂ , Bryan J Pfister ₁

Affiliation

Millions suffer a traumatic brain injury (TBI) each year wherein the outcomes associated with injury can vary greatly between individuals. This study postulates that variations in each biomechanical parameter of a head trauma lead to differences in histological and behavioral outcome measures that should be considered collectively in assessing injury. While trauma severity typically scales with the magnitude of injury, much less is known about the effects of rate and duration of the mechanical insult. In this study, a newly developed voice‐coil fluid percussion injury system was used to investigate the effects of injury rate and fluid percussion impulse on a collection of post‐injury outcomes in male rats. Collectively the data suggest a potential shift in the specificity and progression of neuronal injury and function rather than a general scaling of injury severity. While a faster, shorter fluid percussion first presents as a mild TBI, neuronal loss and some behavioral tasks were similar among the slower and faster fluid percussion injuries. This study concludes that the sequelae of neuronal degeneration and behavioral outcomes are related to the complete temporal profile of the fluid percussion and do not scale only with peak pressure.

中文翻译：

雄性大鼠实验性创伤性脑损伤的结果测量因损伤事件的完整时间生物力学特征而异。

每年有数百万人遭受创伤性脑损伤 (TBI)，其中与损伤相关的结果可能因人而异。该研究假设头部外伤的每个生物力学参数的变化会导致组织学和行为结果测量的差异，在评估损伤时应综合考虑这些差异。虽然创伤严重程度通常与损伤程度成正比，但对机械损伤的速率和持续时间的影响知之甚少。在这项研究中，新开发的音圈流体冲击损伤系统用于研究损伤率和流体冲击脉冲对雄性大鼠一系列损伤后结果的影响。总的来说，数据表明神经元损伤和功能的特异性和进展可能发生变化，而不是损伤严重程度的一般标度。虽然更快、更短的液体冲击首先表现为轻度 TBI，但神经元丢失和一些行为任务在较慢和较快的液体冲击损伤中是相似的。该研究得出的结论是，神经元变性的后遗症和行为结果与流体冲击的完整时间分布有关，并且不仅仅与峰值压力成比例。

更新日期：2020-09-14

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