Intermittent parathyroid hormone promotes cementogenesis via ephrinB2-EPHB4 forward signaling.,Journal of Cellular Physiology

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Intermittent parathyroid hormone promotes cementogenesis via ephrinB2-EPHB4 forward signaling.
Journal of Cellular Physiology ( IF 4.5 ) Pub Date : 2020-08-01 , DOI: 10.1002/jcp.29994
Tiancheng Li _{1,

2} , Han Wang _{1,

2} , Chunxiao Lv _{1,

2} , Li Huang _{1,

2} , Cheng Zhang _{1,

2} , Chenchen Zhou _{1,

3} , Shujuan Zou _{1,

2} , Peipei Duan _{1,

2}

Affiliation

Intermittent parathyroid hormone (PTH) promotes periodontal repair, but the underlying mechanisms remained unclear. Recent studies found that ephrinB2‐EPHB4 forward signaling mediated the anabolic effect of PTH in bone homeostasis. Considering the similarities between cementum and bone, we aimed to examine the therapeutic effect of PTH on resorbed roots and explore the role of forward signaling in this process. In vivo experiments showed that intermittent PTH significantly accelerated the regeneration of root resorption and promoted expression of EPHB4 and ephrinB2. When the signaling was blocked, the resorption repair was also delayed. In vitro studies showed that intermittent PTH promoted the expression of EPHB4 and ephrinB2 in OCCM‐30 cells. The effects of PTH on the mineralization capacity of OCCM‐30 cells was mediated through the ephrinB2‐EPHB4 forward signaling. These results support the premise that the anabolic effects of intermittent PTH on the regeneration of root resorption is via the ephrinB2‐EPHB4 forward signaling pathway.

中文翻译：

间歇性甲状旁腺激素通过 ephrinB2-EPHB4 正向信号促进牙骨质形成。

间歇性甲状旁腺激素（PTH）促进牙周修复，但其潜在机制仍不清楚。最近的研究发现 ephrinB2-EPHB4 正向信号介导 PTH 在骨稳态中的合成代谢作用。考虑到牙骨质和骨之间的相似性，我们旨在检查 PTH 对吸收牙根的治疗效果，并探讨前向信号在此过程中的作用。体内实验表明，间歇性PTH显着加速根吸收再生，促进EPHB4和ephrinB2的表达。当信号传导被阻断时，吸收修复也会延迟。体外研究表明，间歇性 PTH 促进 OCCM-30 细胞中 EPHB4 和 ephrinB2 的表达。 PTH 对 OCCM-30 细胞矿化能力的影响是通过 ephrinB2-EPHB4 正向信号传导介导的。这些结果支持这样的前提：间歇性 PTH 对牙根吸收再生的合成代谢作用是通过 ephrinB2-EPHB4 前向信号通路实现的。

更新日期：2020-08-01

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