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Two new genetically modified mouse alleles labeling distinct phases of retinal ganglion cell development by fluorescent proteins.
Developmental Dynamics ( IF 2.0 ) Pub Date : 2020-08-02 , DOI: 10.1002/dvdy.233
Yichen Ge 1 , Fuguo Wu 1 , Mobin Cheng 1 , Jonathan Bard 2 , Xiuqian Mu 1, 2
Affiliation  

During development, all retinal cell types arise from retinal progenitor cells (RPCs) in a step‐wise fashion. Atoh7 and Pou4f2 mark, and function in, two phases of retinal ganglion cell (RGC) genesis; Atoh7 functions in a subpopulation of RPCs to render them competent for the RGC fate, whereas Pou4f2 participates in RGC fate specification and RGC differentiation. Despite extensive research on their roles, the properties of the two phases represented by these two factors have not been well studied, likely due to the retinal cellular heterogeneity.

中文翻译:


两个新的转基因小鼠等位基因通过荧光蛋白标记视网膜神经节细胞发育的不同阶段。



在发育过程中,所有视网膜细胞类型均以逐步方式由视网膜祖细胞(RPC)产生。 Atoh7 和 Pou4f2 标记视网膜神经节细胞 (RGC) 发生的两个阶段并在其中发挥作用; Atoh7 在 RPC 亚群中发挥作用,使其能够参与 RGC 命运,而 Pou4f2 参与 RGC 命运规范和 RGC 分化。尽管对它们的作用进行了广泛的研究,但这两个因素所代表的两个阶段的特性尚未得到很好的研究,可能是由于视网膜细胞的异质性。
更新日期:2020-08-02
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