We present novel data concerning the time-course of adaptations and potential benefits of heat acclimation for people with cystic fibrosis (pwCF), who are at greater risk of exertional heat illness. A 25-year-old male (genotype: delta-F508 and RH117, forced expiratory volume in 1-second: 77% predicted and baseline sweat [Na+]: 70 mmol·L - 1), who had previously experienced muscle cramping during exercise in ambient heat, underwent 10-sessions of heat acclimation (90-min at 40°C and in 40% relative humidity). Adaptations included; lower resting core temperature (-0.40°C) and heart rate (-6 beats·min-1), plasma volume expansion (+6.0%) and, importantly, increased sweat loss (+370 mL) and sweat gland activity (+12 glands·cm2) with decreased sweat [Na+] (-18 mmol·L - 1). Adaptations were maintained for at least 7-days, with no evidence of cramping during follow-up exercise-heat stress testing. These data suggest pwCF may benefit from heat acclimation to induce sudomotor function improvements, particularly reductions in sweat [Na+], however, further research is required.

中文翻译：

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热适应可改善囊性纤维化成人的汗腺功能并降低汗液钠浓度

我们提供了有关适应时间过程的新数据以及热适应对囊性纤维化 (pwCF) 患者的潜在益处，这些人患劳累性热病的风险更大。一名 25 岁男性（基因型：delta-F508 和 RH117，1 秒用力呼气量：77% 预测值和基线汗液 [Na+]：70 mmol·L - 1），之前曾在运动中出现肌肉痉挛在环境高温下，进行了 10 次热适应（40°C 和 40% 相对湿度下 90 分钟）。包括改编；较低的静息核心温度 (-0.40°C) 和心率 (-6 beats·min-1)，血浆体积膨胀 (+6.0%)，更重要的是，增加汗液流失 (+370 mL) 和汗腺活动 (+12腺体·cm2) 减少汗液 [Na+] (-18 mmol·L - 1)。适应保持至少 7 天，在后续运动热压力测试期间没有抽筋的证据。这些数据表明 pwCF 可能受益于热适应以诱导促汗功能改善，特别是减少汗液 [Na+]，但是，还需要进一步的研究。