Abstract With the booming development of smartphones in our routine lives, the integration of advanced medical technologies and mobile health (mHealth) to manage disease has become an irresistible trend. To extend quality tumour treatment into daily lives, a mHealth platform was developed by using ferroelectric BiFeO3 nanomaterials (BFO) modified with TAT peptide (TAT-BFO) and a smartphone-controlled wearable device. With the control of wearable device, TAT-BFO could be enriched in tumour site via magnetic targeting, and then triggered to generate reactive oxygen species (ROS) for efficient tumour therapy through temperature fluctuation. In both murine orthotopic breast tumour and resectable breast tumour models, this mHealth platform was demonstrated to inhibit tumour growth and prevent tumour recurrence significantly. Moreover, the transcriptomics and multiphysics simulation analysis further elucidated the working mechanism of the mHealth platform. This mHealth platform exhibits great potential for guiding daily-treatment and simplifying clinical treatment of tumour.

中文翻译：

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mHealth：用于肿瘤治疗的智能手机控制的可穿戴平台

摘要 随着智能手机在我们日常生活中的蓬勃发展，将先进的医疗技术与移动健康（mHealth）相结合来管理疾病已成为不可阻挡的趋势。为了将高质量的肿瘤治疗扩展到日常生活中，使用 TAT 肽 (TAT-BFO) 修饰的铁电 BiFeO3 纳米材料 (BFO) 和智能手机控制的可穿戴设备开发了 mHealth 平台。在可穿戴设备的控制下，TAT-BFO可以通过磁性靶向富集在肿瘤部位，然后通过温度波动触发产生活性氧（ROS）进行有效的肿瘤治疗。在鼠原位乳腺肿瘤和可切除乳腺肿瘤模型中，该 mHealth 平台被证明可以显着抑制肿瘤生长并防止肿瘤复发。而且，转录组学和多物理场仿真分析进一步阐明了mHealth平台的工作机制。该 mHealth 平台在指导日常治疗和简化肿瘤临床治疗方面具有巨大潜力。