Background

Small cell carcinoma of ovary, hypercalcemia type (SCCOHT), also known as the malignant rhabdoid tumor of the ovary, is a rare and highly aggressive malignancy affecting younger women. The pathogenesis involves mutations in SWI/SNF-related, matrix-associated, actin-dependent regulator chromatin group A4 (SMARCA4)/Brahma-related gene 1 (BRG1) and/or SWI/SNF-related, matrix-associated, actin-dependent regulator chromatin group A2 (SMARCA2)/Brahma homolog (BRM).

Case

A 10-year-old girl presented with lower abdominal pain and a mass for the past 2 weeks. She underwent ultrasound-guided fine needle aspiration and core needle biopsy from the pelvic mass followed by surgery. On the basis of the characteristic morphologic and immunohistochemical features, a diagnosis of SCCOHT was rendered. Chemotherapy was started, however, she succumbed to the disease.

中文翻译：

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卵巢小细胞癌，高钙血症类型：罕见病例的细胞学，组织病理学和免疫组织化学研究。

背景

卵巢小细胞癌，高钙血症型（SCCOHT），也称为卵巢恶性横纹肌瘤，是一种罕见且高度侵袭性的恶性肿瘤，影响年轻女性。发病机理涉及SWI / SNF相关，基质相关，肌动蛋白依赖性调节染色质组A4（SMARCA 4）/婆罗门相关基因1（BRG1）和/或SWI / SNF相关，基质相关，肌动蛋白-突变依赖性调节子染色质组A2（SMARCA2）/婆罗门同源（BRM）。

案件

在过去的2周中，有一个10岁的女孩出现下腹部疼痛和肿块。她接受了来自盆腔肿块的超声引导下的细针穿刺活检和核心针穿刺活检，然后进行了手术。根据特征性形态学和免疫组化特征，对SCCOHT进行诊断。开始化疗后，她屈服于这种疾病。