The use of a single family of dietary bioactive compounds has not been sufficient to manage highly regulated mechanisms such as body weight. Therefore, we aimed to evaluate the effect of a multifunctional ingredient (MIX) based on the co-administration of a low dose of conjugated linoleic acid with the protein hydrolysate from chicken feet, Hpp11, and a mixture of grape-seed proanthocyanidins and berry anthocyanins on body weight management in obese rats fed a cafeteria diet. The daily oral administration of the MIX for three weeks significantly reversed obesity and hyperleptinemia and increased energy expenditure and fat oxidation. In addition, animals administered the MIX exhibited greater hypothalamic activation of STAT3 in POMC-expressing neurons than non-supplemented animals. Our results strongly suggest that the co-administration of different bioactive compounds could be a promising strategy to complement the existing therapies against obesity and leptin resistance.

膳食生物活性化合物的单一家族的使用不足以管理诸如体重之类的高度受控的机制。因此，我们旨在基于低剂量的共轭亚油酸与鸡脚的蛋白水解产物Hpp11以及葡萄籽原花色素和浆果花色苷的混合物的共同给药，来评估多功能成分（MIX）的效果肥胖饮食的饮食管理对肥胖大鼠的影响。每天口服MIX三周可显着逆转肥胖症和高瘦素血症，并增加能量消耗和脂肪氧化。此外，与未补充动物相比，给予MIX的动物在表达POMC的神经元中表现出更大的下丘脑激活STAT3。