OBJECTIVE Few studies have explored the association between inflammation and eating disorders and none used a longitudinal design. We investigated the association between serum-levels of interleukin 6(IL-6) and C-reactive protein (CRP) measured in childhood and eating disorders and related behaviours and cognitions in adolescence in a large general population sample. METHODS We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC). Our exposures were thirds of IL6 and CRP derived from serum measurements taken at age nine years, and outcomes were eating disorder diagnoses and self-reported disordered eating behaviours at ages 14, 16, and 18 years. We used univariable and multivariable multilevel logistic regression models adjusting for a number of potential confounders, including sex, fat mass, and pre-existing mental health difficulties. RESULTS Our sample included 3,480 children. Those in the top third of CRP had lower odds of binge eating (odds ratio(OR):0.62, 95% confidence interval(CI):0.39,1.00,p "equals" 0.05) and fasting (OR:0.63, 95% CI:0.38,1.07,p "equals" 0.09) after adjustment for confounders. We also observed weak associations of comparable magnitude for purging, anorexia nervosa, and bulimia nervosa. We did not find any associations between levels of IL6 and any of the outcomes under study. CONCLUSIONS There was little evidence of an association between CRP and IL-6 and adolescent eating disorder outcomes. The inverse association observed between CRP and binge eating was unexpected, so caution is needed when interpreting it. One possible explanation is that higher CRP levels could have a protective role for disordered eating by affecting appetitive traits.

中文翻译：

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儿童期循环白细胞介素 6 和 C 反应蛋白与青春期饮食失调和饮食失调之间的纵向关联

目的 很少有研究探讨炎症与饮食失调之间的关联，也没有使用纵向设计。我们在大型普通人群样本中研究了儿童时期测量的白细胞介素 6 (IL-6) 和 C 反应蛋白 (CRP) 血清水平与饮食失调以及青春期相关行为和认知之间的关联。方法 我们使用了雅芳家长和儿童纵向研究 (ALSPAC) 的数据。我们暴露的 IL6 和 CRP 的三分之一来自 9 岁时进行的血清测量，结果是 14、16 和 18 岁时的饮食失调诊断和自我报告的饮食失调行为。我们使用单变量和多变量多级逻辑回归模型来调整许多潜在的混杂因素，包括性别、脂肪量和预先存在的心理健康问题。结果 我们的样本包括 3,480 名儿童。CRP 排名前三分之一的人暴食（优势比 (OR)：0.62，95% 置信区间 (CI)：0.39,1.00，p“等于”0.05）和禁食（OR：0.63，95% CI）的几率较低：0.38,1.07,p“等于”0.09）在调整混杂因素后。我们还观察到与清除、神经性厌食症和神经性贪食症之间具有相当程度的弱关联。我们没有发现 IL6 水平与所研究的任何结果之间存在任何关联。结论 几乎没有证据表明 CRP 和 IL-6 与青少年饮食失调结果之间存在关联。CRP 与暴饮暴食之间观察到的负相关是出乎意料的，因此在解释它时需要谨慎。一种可能的解释是，较高的 CRP 水平可能通过影响食欲特征对饮食失调起到保护作用。