Vascularization is one of the key steps for engraftment in regenerative medicine. Previously one of the authors had discovered peptides exhibiting significant angiogenic activities designated AGP and elucidated the active core. For neovascularization basic fibroblast growth factor is used although permeation can be envisaged. The original AGPs did not suffer from this although their half-life times are short because of decomposition by endogenous enzymes. Several new AGP-libraries have been constructed and their enzymatic resistance has been investigated by the use of human umbilical vein endothelial cells to find candidates for clinical applications.

中文翻译：

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用于临床应用的具有血管生成活性的肽的改良设计。

血管化是再生医学中植入的关键步骤之一。以前，一位作者发现了表现出显着血管生成活性的肽（称为AGP）并阐明了活性核心。对于新血管形成，使用碱性成纤维细胞生长因子，尽管可以设想渗透。最初的AGP尽管由于内源酶的分解而使半衰期很短，但并未遭受此困扰。已经构建了几种新的AGP文库，并且已经通过使用人脐静脉内皮细胞研究了它们的酶抗性以寻找临床应用的候选药物。