Purpose

Behçet’s disease (BD) is a multisystemic perivasculitis with recurrent oral aphthous ulcers, genital ulcers, and eye involvement which was first described in 1937. Neurological involvement in BD patients is referred to as neuro-Behçet’s disease (NBD). Studies have shown that BD worsens quality of life. However, there is no study that conducts a head-to-head comparison of quality of life between NBD patients and healthy controls.

Methods

Forty patients with NBD and 39 age-sex-matched healthy control subjects were included in this study. Sociodemographic data of all participants were recorded; SF-36 was used to assess quality of life.

Results

NBD patients had significantly lower SF-36 scores of physical functioning, physical difficulty, bodily pain, and general health perception compared with healthy controls. However, there was no significant difference between the groups according to the SF-36 scores of role limitation due to emotional problems, mental health, vitality, and social functioning. There was no significant difference between parenchymal and non-parenchymal NBD groups according to SF-36, Beck’s Depression Inventory, and Beck’s Anxiety Inventory scores. Patients with cerebellar system involvement had significantly lower physical and social functioning scores compared with those who did not. Patients with brain stem involvement were found to have higher role limitation due to emotional problems, vitality, social functioning, physical pain, and general health perception scores compared with those without brain stem findings.

Conclusions

NBD negatively affects many aspects of the quality of life.

中文翻译：

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神经贝塞特氏病的生活质量：一项横断面研究。

目的

Behçet病（BD）是一种多系统性血管周炎，伴有反复出现的口腔口疮，生殖器溃疡和眼睛受累，最早于1937年被描述。BD患者的神经系统受累被称为神经性Beheçet病（NBD）。研究表明，BD会恶化生活质量。但是，尚无一项研究对NBD患者和健康对照者的生活质量进行正面对比。

方法

这项研究包括40名NBD患者和39名年龄性别匹配的健康对照者。记录所有参与者的社会人口统计学数据；SF-36用于评估生活质量。

结果

与健康对照组相比，NBD患者的身体功能，身体困难，身体疼痛和总体健康知觉的SF-36得分明显较低。然而，由于情绪问题，心理健康，活力和社交功能，根据角色限制的SF-36评分，两组之间没有显着差异。根据SF-36，贝克的抑郁量表和贝克的焦虑量表评分，实质性和非实质性NBD组之间无显着差异。与没有小脑系统受累的患者相比，小脑系统受累的患者的身体和社交功能得分明显较低。由于情感问题，生命力，社交功能，身体疼痛，

结论

NBD对生活质量的许多方面产生负面影响。