Abstract

Parkinson’s disease (PD) is a condition that predominantly affects older people. It is imperative that clinical management considers the other significant illnesses that people with PD accumulate as they age in conjunction with their resilience to cope with physiological change. Multimorbidity and frailty act synergistically to heighten the risk of adverse outcomes for older people with PD. These states are associated with increased likelihood of hospitalisation, polypharmacy, adverse drug effects including the anticholinergic burden of medications, drug-disease and drug-drug interactions. Management should be integrated, holistic and individualised to meticulously balance the risks of interventions considering the vulnerability of the individual to recover from disturbance to their environmental, physical and cognitive equilibrium.

中文翻译：

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多重发病和虚弱：解决帕金森病的复杂性。

 抽象的

帕金森病 (PD) 是一种主要影响老年人的疾病。临床管理必须考虑帕金森病患者随着年龄的增长而积累的其他重大疾病，以及他们应对生理变化的能力。多发病和虚弱协同作用，增加了老年帕金森病患者出现不良后果的风险。这些状态与住院治疗、多重用药、药物不良反应（包括药物的抗胆碱能负担）、药物与疾病以及药物与药物相互作用的可能性增加有关。管理应该是综合的、整体的和个性化的，以仔细平衡干预措施的风险，考虑到个人从环境、身体和认知平衡的干扰中恢复的脆弱性。