The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific expression of the host cell surface receptor is necessary. The key protein suggested to be involved in host cell entry is angiotensin I converting enzyme 2 (ACE2). Here, we report the expression pattern of ACE2 across > 150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis. The results were compared with several datasets both on the mRNA and protein level. ACE2 expression was mainly observed in enterocytes, renal tubules, gallbladder, cardiomyocytes, male reproductive cells, placental trophoblasts, ductal cells, eye, and vasculature. In the respiratory system, the expression was limited, with no or only low expression in a subset of cells in a few individuals, observed by one antibody only. Our data constitute an important resource for further studies on SARS‐CoV‐2 host cell entry, in order to understand the biology of the disease and to aid in the development of effective treatments to the viral infection.

中文翻译：

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人体组织中 ACE2 的蛋白表达谱。

新型 SARS 冠状病毒 2 (SARS-CoV-2) 对医疗保健和社会提出了全球性挑战。为了了解 SARS-CoV-2 感染的易感性，宿主细胞表面受体的细胞类型特异性表达是必要的。参与宿主细胞进入的关键蛋白质是血管紧张素 I 转换酶 2 (ACE2)。在这里，我们基于严格的免疫组织化学分析，报告了对应于所有主要人体组织和器官的超过 150 种不同细胞类型中 ACE2 的表达模式。将结果与几个数据集在 mRNA 和蛋白质水平上进行了比较。ACE2表达主要在肠上皮细胞、肾小管、胆囊、心肌细胞、男性生殖细胞、胎盘滋养层细胞、导管细胞、眼睛和脉管系统中观察到。在呼吸系统中，表达是有限的，仅通过一种抗体观察到，在少数个体的细胞子集中没有或仅有低表达。我们的数据构成了进一步研究 SARS-CoV-2 宿主细胞进入的重要资源，以了解该疾病的生物学并帮助开发针对病毒感染的有效治疗方法。