The ability to control the relative motions of component parts in molecules is essential for the development of molecular nanotechnology. The advent of mechanically interlocked molecules (MIMs) has enhanced significantly the opportunities for chemists to harness such motions in artificial molecular machines (AMMs). Recently, we have developed artificial molecular pumps (AMPs) capable of producing highly energetic oligo- and polyrotaxanes with high precision. Here, we report the design, synthesis, and operation of an AMP incorporating a photocleavable stopper that allows for the use of orthogonal stimuli. Our approach employs a ratchet mechanism to pump a ring onto a collecting chain, forming an intermediate [2]rotaxane. At a subsequent time, application of light triggers the release of the ring back into the bulk solution with temporal control. This process is monitored by the quenching of the fluorescence of a naphthalene-based fluorophore. This design may find application in the fabrication of molecular transporting systems with on-demand functions.

中文翻译：

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响应电和光而运行的人工分子泵

控制分子中组成部分相对运动的能力对于分子纳米技术的发展至关重要。机械互锁分子 (MIM) 的出现大大增加了化学家在人工分子机器 (AMM) 中利用此类运动的机会。最近，我们开发了能够高精度生产高能低聚轮烷和聚轮烷的人工分子泵 (AMP)。在这里，我们报告了一个 AMP 的设计、合成和操作，该 AMP 包含一个允许使用正交刺激的可光裂解塞子。我们的方法采用棘轮机制将环泵送到收集链上，形成中间 [2] 轮烷。在随后的时间，光的应用触发环的释放回到具有时间控制的本体溶液中。该过程通过萘基荧光团的荧光猝灭来监测。这种设计可以应用于制造具有按需功能的分子传输系统。