Thiol-containing natural products possess a wide range of bioactivities. The burst of synthetic biology technology facilitates the discovery of new thiol-containing active ingredients. Herein, we report a sensitive, quick, and robust surface-enhanced Raman scattering technology for specific and multiplex detection of thiol-containing compounds without purification requirements and also indicating the thiols with different chemical environments. Using this platform, we successfully demonstrated the simultaneous detection of thiol-containing compounds from as low as 1 μM of analytes spiked in complex culture matrices.

中文翻译：

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培养复合物中含硫醇的天然产物的SERS快速检测。

含硫醇的天然产物具有广泛的生物活性。合成生物学技术的爆发促进了新的含硫醇活性成分的发现。在本文中，我们报告了一种灵敏，快速且耐用的表面增强拉曼散射技术，可用于无需纯化要求的特异性和多重检测含硫醇的化合物，还可以指示具有不同化学环境的硫醇。使用此平台，我们成功地证明了含硫醇的化合物的从低至同时检测作为1  μ M在复杂的培养基质掺入分析物。