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Capturing Multicellular System Designs Using Synthetic Biology Open Language (SBOL).
ACS Synthetic Biology ( IF 4.7 ) Pub Date : 2020-07-31 , DOI: 10.1021/acssynbio.0c00176
Bradley Brown 1 , Bryan Bartley 2 , Jacob Beal 2 , Jasmine E Bird 3 , Ángel Goñi-Moreno 4, 5 , James Alastair McLaughlin 4 , Göksel Mısırlı 6 , Nicholas Roehner 2 , David James Skelton 4 , Chueh Loo Poh 7 , Irina Dana Ofiteru 1 , Katherine James 8 , Anil Wipat 4
Affiliation  

Synthetic biology aims to develop novel biological systems and increase their reproducibility using engineering principles such as standardization and modularization. It is important that these systems can be represented and shared in a standard way to ensure they can be easily understood, reproduced, and utilized by other researchers. The Synthetic Biology Open Language (SBOL) is a data standard for sharing biological designs and information about their implementation and characterization. Previously, this standard has only been used to represent designs in systems where the same design is implemented in every cell; however, there is also much interest in multicellular systems, in which designs involve a mixture of different types of cells with differing genotype and phenotype. Here, we show how the SBOL standard can be used to represent multicellular systems, and, hence, how researchers can better share designs with the community and reliably document intended system functionality.

中文翻译:

使用合成生物学开放语言 (SBOL) 捕获多细胞系统设计。

合成生物学旨在利用标准化和模块化等工程原理开发新的生物系统并提高其可重复性。重要的是,这些系统可以以标准方式表示和共享,以确保其他研究人员可以轻松理解、复制和使用它们。合成生物学开放语言 (SBOL) 是一种数据标准,用于共享生物学设计以及有关其实施和表征的信息。以前,该标准仅用于表示在每个单元中实施相同设计的系统中的设计;然而,人们对多细胞系统也很感兴趣,其中设计涉及具有不同基因型和表型的不同类型细胞的混合物。这里,
更新日期:2020-09-20
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