Plasma medicine is an innovative research field combining plasma physics, life science, and clinical medicine. It is mainly focused on the application cold atmospheric plasma (CAP) in therapeutic settings. Based on its ability to inactivate microorganisms but also to stimulate tissue regeneration, current medical applications are focused on the treatment of wounds and skin diseases. Since CAP is also able to inactivate cancer cells, its use in cancer therapy is expected to be the next field of clinical plasma application. Other promising applications are expected in oral medicine and ophthalmology. It is the current state of knowledge that biological CAP effects are mainly based on the action of reactive oxygen and nitrogen species supported by electrical fields and UV radiation. However, continuing basic research is not only essential to improve, optimize, and enlarge the spectrum of medical CAP applications and their safety, but it is also the basis for identification and definition of a single parameter or set of parameters to monitor and control plasma treatment and its effects. In the field of CAP plasma devices, research and application are currently dominated by two basic types: dielectric barrier discharges and plasma jets. Its individual adaptation to specific medical needs, including its combination with technical units for continuous and real-time monitoring of both plasma performance and the target that is treated, will lead to a new generation of CAP-based therapeutic systems.

中文翻译：

---

冷大气等离子体 (CAP) 在医学中的应用前景

等离子体医学是一个结合等离子体物理、生命科学和临床医学的创新研究领域。它主要侧重于冷大气等离子体 (CAP) 在治疗环境中的应用。基于其灭活微生物和刺激组织再生的能力，目前的医学应用集中在伤口和皮肤病的治疗上。由于 CAP 还能够灭活癌细胞，因此它在癌症治疗中的应用有望成为临床血浆应用的下一个领域。预计其他有希望的应用在口腔医学和眼科。目前的知识状态是，生物 CAP 效应主要基于电场和紫外线辐射支持的活性氧和氮物种的作用。然而，持续的基础研究不仅对提高、优化和扩大医疗 CAP 应用及其安全性的范围，但它也是识别和定义单个参数或一组参数以监测和控制等离子体处理及其效果的基础。在CAP等离子体器件领域，目前研究和应用主要有两种基本类型：介质阻挡放电和等离子体射流。它对特定医疗需求的个性化适应，包括与技术单元相结合，以连续实时监测血浆性能和治疗目标，将催生新一代基于 CAP 的治疗系统。但它也是识别和定义单个参数或一组参数以监测和控制等离子体处理及其效果的基础。在CAP等离子体器件领域，目前研究和应用主要有两种基本类型：介质阻挡放电和等离子体射流。它对特定医疗需求的个性化适应，包括与技术单元相结合，以连续实时监测血浆性能和治疗目标，将催生新一代基于 CAP 的治疗系统。但它也是识别和定义单个参数或一组参数以监测和控制等离子体处理及其效果的基础。在CAP等离子体器件领域，目前研究和应用主要有两种基本类型：介质阻挡放电和等离子体射流。它对特定医疗需求的个性化适应，包括与技术单元相结合，以连续实时监测血浆性能和治疗目标，将催生新一代基于 CAP 的治疗系统。