From Selenite to Diselenide-Containing Drug Delivery Systems,ACS Materials Letters

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From Selenite to Diselenide-Containing Drug Delivery Systems
ACS Materials Letters ( IF 9.6 ) Pub Date : 2020-07-31 , DOI: 10.1021/acsmaterialslett.0c00272
Chenxing Sun ₁ , Yizheng Tan ₁ , Huaping Xu ₁

Affiliation

Nanomaterials are good platforms for the combination of different cancer treatments, such as radiotherapy, chemotherapy, and immunotherapy. However, those materials mostly serve as delivery vehicles for efficient and targeted transport of anticancer drugs. Stimuli-responsive chemical bonds have already been widely applied to construct these nanomaterials for controlled drug release. Diselenide bonds are one example of dual redox responsive bonds. Different from other stimuli-responsive nanomaterials, diselenide-containing polymers can not only function as drug carriers, but also show good anticancer efficiency and immunomodulatory properties after quick and sensitive response to oxidative stimuli. Seleninic acid, the oxidation product of Se–Se bonds, can disturb the redox hemostasis and regulate protein expression in cancer cells. In this Viewpoint, we briefly introduced the significance and applications of diselenide-containing polymers in combined anticancer treatment. Furthermore, we envisioned the future challenges and directions of diselenide-containing drug delivery systems.

中文翻译：

从亚硒酸盐到含二硒化物的药物输送系统

纳米材料是组合多种癌症治疗方法（例如放射疗法，化学疗法和免疫疗法）的良好平台。但是，这些材料主要用作有效和有针对性地运输抗癌药物的载体。刺激响应性化学键已被广泛应用于构建这些纳米材料以控制药物的释放。二硒键是双重氧化还原响应键的一个例子。与其他刺激响应性纳米材料不同，含二硒化物的聚合物不仅可以起药物载体的作用，而且在对氧化刺激性做出快速而敏感的反应后，还表现出良好的抗癌效果和免疫调节特性。硒酸（Se-Se键的氧化产物）可以干扰氧化还原止血并调节癌细胞中的蛋白质表达。本着这一观点，我们简要介绍了含二硒化物的聚合物在联合抗癌治疗中的意义和应用。此外，我们设想了含二硒化物的药物递送系统的未来挑战和方向。

更新日期：2020-09-08

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