Depressive symptoms could be considered a mutual manifestation of major depressive disorder and schizophrenia. Rs3758391 is a functional locus of Sirtuin (SIRT1) involving depression etiology. In this study, we hypothesized that the SIRT1 SNP rs3758391 might be a hazard for schizophrenia pathogenesis, especially related to the appearance of depressive symptoms. We recruited 723 healthy controls and 715 schizophrenia patients, the occurrence of psychotic and depressive symptoms was evaluated by Calgary Depression Scale (CDSS) and PANSS. Meanwhile, qt-PCR was used to detect the mRNA levels of SIRT1 in peripheral blood of 197 olanzapine monotherapy schizophrenia patients. 45.6% of schizophrenia patients had depressive symptoms. In the patient group, mRNA levels of patients with depressive symptoms were significantly lower than those without depressive symptoms (P < 0.01). CDSS scores of schizophrenia patients with different rs3758391 genotypes were significantly different (P < 0.01). Post hoc comparisons indicated that the CDSS scores of rs3758391 C/C and C/T carriers were higher than those of T/T carriers (Ps < 0.01). In the occipital cortex, our eQTL analysis showed that there was a clear correlation between rs3758391 and the SIRT1 mRNA levels. Our preliminary findings provide suggestive evidence that SIRT1 makes schizophrenia patients more prone to depressive symptoms. This SNP might be a biomarker of depression in schizophrenia.

抑郁症状可以被认为是主要抑郁症和精神分裂症的共同表现。Rs3758391是Sirtuin（SIRT1）的一个功能位点，涉及抑郁症的病因。在这项研究中，我们假设SIRT1 SNP rs3758391可能是精神分裂症发病的危险因素，尤其与抑郁症状的出现有关。我们招募了723名健康对照者和715名精神分裂症患者，通过卡尔加里抑郁量表（CDSS）和PANSS评估了精神病和抑郁症状的发生。同时，采用qt-PCR检测197例奥氮平单药治疗精神分裂症患者外周血SIRT1的mRNA水平。45.6％的精神分裂症患者有抑郁症状。在患者组中，P<0.01）。不同基因型rs3758391的精神分裂症患者的CDSS评分存在显着差异（P <0.01）。 事后比较表明，rs3758391 C / C和C / T携带者的CDSS评分高于T / T携带者的CDSS评分（Ps <0.01）。在枕叶皮质中，我们的eQTL分析表明rs3758391与SIRT1 mRNA水平之间存在明显的相关性。我们的初步发现提供了暗示性证据，表明SIRT1使精神分裂症患者更容易出现抑郁症状。该SNP可能是精神分裂症中抑郁症的生物标志。