The worldwide emergence of microbial resistance to available antibiotics presents a global threat to public health and health systems. This special issue aimed to gather papers describing novel antibiotics, originating form chemical synthesis, repurposing of existent drugs, or from natural sources like plant extracts, herbs and spices. A total of 13 papers were published, covering a wide range of topic, including antimicrobial resistance surveillance studies; synthesis of novel molecules with antimicrobial activities; modification or repurposing of already existing molecules, plant-derived active extracts, and molecules; the effects of antimicrobial therapy on microbiota; and the investigation of novel formulations for human and veterinary uses. After decades of antibiotics discovery decline, antibiotics discovery is boosting. Recent developments of post genomics approaches and bioinformatics tools will most certainly turn the tide in the discovery and development of antimicrobials in this exciting field.

中文翻译：

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抗菌化合物的新见解：从合成和发现到分子作用机理。

微生物对可用抗生素的耐药性在全球范围内出现，这对公共卫生和卫生系统构成了全球性威胁。本期专刊旨在收集描述新型抗生素，化学合成来源，现有药物的再利用或天然来源（例如植物提取物，草药和香料）的论文。共发表了13篇论文，涵盖了广泛的主题，包括抗菌素耐药性监测研究；具有抗菌活性的新型分子的合成；修改或重新利用已经存在的分子，植物来源的活性提取物和分子；抗菌治疗对微生物的影响；以及用于人类和兽医用途的新型制剂的研究。在数十年的抗生素发现下降之后，抗生素发现正在加速发展。