Antimicrobial resistance (AMR) is one of the most complex global health challenges today: decades of overuse and misuse in human medicine, animal health, agriculture, and dispersion into the environment have produced the dire consequence of infections to become progressively untreatable. Infection control and prevention (IPC) procedures, the reduction of overuse, and the misuse of antimicrobials in human and veterinary medicine are the cornerstones required to prevent the spreading of resistant bacteria. Purified drinking water and strongly improved sanitation even in remote areas would prevent the pollution from inadequate treatment of industrial, residential, and farm waste, as all these situations are expanding the resistome in the environment. The One Health concept addresses the interconnected relationships between human, animal, and environmental health as a whole: several countries and international agencies have now included a One Health Approach within their action plans to address AMR. Improved antimicrobial usage, coupled with regulation and policy, as well as integrated surveillance, infection control and prevention, along with antimicrobial stewardship, sanitation, and animal husbandry should all be integrated parts of any new action plan targeted to tackle AMR on the Earth. Since AMR is found in bacteria from humans, animals, and in the environment, we briefly summarize herein the current concepts of One Health as a global challenge to enable the continued use of antibiotics.

中文翻译：

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国家收入只是其中之一：人类，动物和环境之间的抗微生物药物耐药性全球之旅。

抗菌素耐药性（AMR）是当今全球最复杂的健康挑战：人类医学，动物健康，农业中数十年的过度使用和误用以及向环境中的扩散已导致感染的可怕后果，使之变得无法治愈。感染控制和预防（IPC）程序，减少过度使用以及在人和兽药中滥用抗菌素是防止耐药菌传播所需的基础。即使在偏远地区，纯净的饮用水和强烈改善的卫生条件也可以防止对工业，住宅和农场废物的处理不当造成污染，因为所有这些情况都在扩大环境中的抵抗力。“一个健康”概念解决了人，动物，与整体环境卫生：一些国家和国际机构现在已在其应对AMR的行动计划中纳入了“一种健康方法”。改善抗菌剂的使用，再加上法规和政策，以及综合的监测，感染控制和预防，以及抗菌素的管理，卫生和畜牧业，都应成为旨在解决地球上AMR的任何新行动计划的组成部分。以来 畜牧业应成为旨在解决地球上AMR的任何新行动计划的有机组成部分。以来 畜牧业应成为旨在解决地球上AMR的任何新行动计划的有机组成部分。以来 在人类，动物和环境中的细菌中发现了AMR，我们在此简要概述One Health的当前概念，将其作为全球挑战以使抗生素能够继续使用。