Stathmin is a highly conserved microtubule remodeling protein, involved in many biological processes such as signal transduction, cell proliferation, neurogenesis and so on. However, little evolutional information has been reported about this gene family in fish. In this study, 175 stathmin genes were identified in 27 species of fish. Conserved exon-intron structure and motif distributions were found in each group. Divergence of duplicated genes implied the species’ adaptation to the environment. Functional divergence suggested that the evolution of stathmin is mainly influenced by purifying selection, and some residues may undergo positive selection. Moreover, synteny relationship near the stathmin locus was relatively conserved in some fish. Network analyses also exhibited 74 interactions, implying functional diversity. The expression pattern of some stathmin genes was also investigated under pesticide stress. These will provide useful references for their functional research in the future.

中文翻译：

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鱼Stathmin基因的分子进化和表征。

Stathmin是一种高度保守的微管重塑蛋白，参与许多生物过程，例如信号转导，细胞增殖，神经发生等。然而，关于鱼类中该基因家族的进化信息鲜有报道。在这项研究中，在27种鱼类中鉴定出175种Stathmin基因。在每个组中发现保守的外显子-内含子结构和基序分布。复制基因的多样性意味着该物种对环境的适应。功能差异表明，stathmin的进化主要受纯化选择的影响，某些残基可能经历正选择。此外，在某些鱼类中，斯塔斯敏位点附近的同位关系相对保守。网络分析还展示了74种相互作用，这意味着功能的多样性。还研究了农药胁迫下一些stathmin基因的表达模式。这些将为将来的功能研究提供有用的参考。