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Dendritic cells in Th2 immune responses and allergic sensitization.
Immunology and Cell Biology ( IF 3.2 ) Pub Date : 2020-08-01 , DOI: 10.1111/imcb.12387 Olivier Lamiable 1 , Johannes U Mayer 1 , Luis Munoz-Erazo 1 , Franca Ronchese 1
Immunology and Cell Biology ( IF 3.2 ) Pub Date : 2020-08-01 , DOI: 10.1111/imcb.12387 Olivier Lamiable 1 , Johannes U Mayer 1 , Luis Munoz-Erazo 1 , Franca Ronchese 1
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Allergic responses are characterized by the activation of a specific subset of effector CD4+ T cells, the T‐helper type 2 (Th2) cells, that respond to harmless environmental antigens causing inflammation and pathology. Th2 cells are also found in the context of parasite infections, where they can mediate parasite clearance and expulsion, and support tissue repair. The process that leads to the activation of Th2 cells in vivo is incompletely understood: while it has become clear that “conventional” dendritic cells are essential antigen‐presenting cells for the initiation of Th2 immune responses, the molecules that are expressed by dendritic cells exposed to allergens, and the mediators that are produced as a consequence and signal to naïve CD4+ T cells to promote their development into effector Th2, remain to be defined. Here we summarize recent developments in the identification of the dendritic cell subsets involved in Th2 responses, review potential mechanisms proposed to explain the generation of these immune responses, and discuss the direct and indirect signals that condition dendritic cells to drive the development of Th2 responses during allergen or parasite exposure.
中文翻译：
Th2 免疫反应和过敏致敏中的树突状细胞。
过敏反应的特征是激活特定的效应 CD4 + T 细胞亚群，即 T 辅助型 2 (Th2) 细胞，它们对引起炎症和病理的无害环境抗原做出反应。Th2 细胞也存在于寄生虫感染的背景下，它们可以介导寄生虫清除和排出，并支持组织修复。导致体内Th2 细胞活化的过程尚不完全清楚：虽然“常规”树突细胞是启动 Th2 免疫反应必不可少的抗原呈递细胞，但暴露的树突细胞表达的分子已变得很明显。过敏原，以及由此产生的介质，并向幼稚的 CD4 +发出信号T 细胞促进其发育为效应 Th2，仍有待确定。在这里，我们总结了识别参与 Th2 反应的树突细胞亚群的最新进展，回顾了解释这些免疫反应产生的潜在机制，并讨论了调节树突细胞以驱动 Th2 反应发展的直接和间接信号。过敏原或寄生虫暴露。
更新日期：2020-08-01
中文翻译：
Th2 免疫反应和过敏致敏中的树突状细胞。
过敏反应的特征是激活特定的效应 CD4 + T 细胞亚群，即 T 辅助型 2 (Th2) 细胞，它们对引起炎症和病理的无害环境抗原做出反应。Th2 细胞也存在于寄生虫感染的背景下，它们可以介导寄生虫清除和排出，并支持组织修复。导致体内Th2 细胞活化的过程尚不完全清楚：虽然“常规”树突细胞是启动 Th2 免疫反应必不可少的抗原呈递细胞，但暴露的树突细胞表达的分子已变得很明显。过敏原，以及由此产生的介质，并向幼稚的 CD4 +发出信号T 细胞促进其发育为效应 Th2，仍有待确定。在这里，我们总结了识别参与 Th2 反应的树突细胞亚群的最新进展，回顾了解释这些免疫反应产生的潜在机制，并讨论了调节树突细胞以驱动 Th2 反应发展的直接和间接信号。过敏原或寄生虫暴露。
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