Novel input polarisation independent endoscopic cross-polarised optical coherence tomography probe.,Journal of Biophotonics

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Novel input polarisation independent endoscopic cross-polarised optical coherence tomography probe.
Journal of Biophotonics ( IF 2.0 ) Pub Date : 2020-08-01 , DOI: 10.1002/jbio.202000134
Katharina Blessing _{1,

2} , Judith Schirmer _{1,

2} , Gargi Sharma ₃ , Kanwarpal Singh _{1,

2}

Affiliation

Lead by the original idea to perform noninvasive optical biopsies of various tissues, optical coherence tomography found numerous medical applications within the last two decades. The interference based imaging technique opens the possibility to visualise subcellular morphology up to an imaging depth of 3 mm and up to micron level axial and lateral resolution. The birefringence properties of the tissue are visualised with enhanced contrast using polarisation sensitive or cross‐polarised optical coherence tomography (OCT) techniques. Although, it requires strict control over the polarisation states, resulting in several polarisation controlling elements. In this work, we propose a novel input‐polarisation independent endoscopic system based on cross‐polarised OCT. We tested the feasibility of our approach by measuring the polarisation change from a quarter‐wave plate for different rotational angles. Further performance tests reveal a lateral resolution of 30 μm and a sensitivity of 103 dB. Images of the human nail bed and cow muscle tissue demonstrate the potential of the system to measure structural and birefringence properties of the tissue endoscopically.

中文翻译：

新型输入偏振无关内窥镜交叉偏振光学相干断层扫描探头。

光学相干断层扫描技术以执行各种组织的非侵入性光学活检为最初的想法，在过去的二十年中发现了许多医疗应用。基于干涉的成像技术为可视化亚细胞形态提供了可能性，成像深度可达3 mm，轴向和横向分辨率达到微米级。使用偏振敏感或交叉偏振光学相干断层扫描（OCT）技术，可以增强对比度来观察组织的双折射特性。虽然，它需要严格控制偏振态，从而导致几个偏振控制元件。在这项工作中，我们提出了一种基于交叉极化OCT的新型输入极化独立内窥镜系统。我们通过测量四分之一波片在不同旋转角度下的偏振变化来测试我们方法的可行性。进一步的性能测试表明，横向分辨率为30 μ米和103 dB的敏感度。人指甲床和牛肌肉组织的图像证明了该系统在内窥镜下测量组织的结构和双折射特性的潜力。

更新日期：2020-08-01

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