Associations between VEGF isoforms and impending retinopathy of prematurity,International Journal of Developmental Neuroscience

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Associations between VEGF isoforms and impending retinopathy of prematurity
International Journal of Developmental Neuroscience ( IF 1.7 ) Pub Date : 2020-08-19 , DOI: 10.1002/jdn.10054
Tammy Z Movsas _{1,

2} , Arivalagan Muthusamy ₁

Affiliation

Vascular Endothelial Growth Factor (VEGF) is the main driver of angiogenesis during neurodevelopment (i.e., brain and retina). VEGF165 and VEGF121 are the two most prevalent human VEGF isoforms. Although retinopathy of prematurity (ROP), a neuroretinal disorder, is associated with VEGF dysregulation, little is known about the interaction of VEGF isoforms on neuroretinal angiogenesis. We hypothesized that: (a) A specific VEGF165/VEGF121 correlation, at a given time point, is associated with normal retinal development (no ROP) and (b) An altered correlation, of such, is associated with aberrant retinal development (ROP). Utilizing pre‐collected dried blood spots (DBS) from <1‐week‐old preterm infants, we aimed to determine whether correlations between VEGF165 and VEGF121 precede the diagnosis of early stage, non‐proliferative ROP (NP‐ROP).

中文翻译：

VEGF 亚型与即将发生的早产儿视网膜病变之间的关联

血管内皮生长因子 (VEGF) 是神经发育（即大脑和视网膜）过程中血管生成的主要驱动因素。VEGF165 和 VEGF121 是两种最普遍的人类 VEGF 亚型。尽管早产儿视网膜病变 (ROP) 是一种神经视网膜疾病，与 VEGF 失调有关，但对 VEGF 同种型对神经视网膜血管生成的相互作用知之甚少。我们假设：(a) 在给定的时间点，特定的 VEGF165/VEGF121 相关性与正常视网膜发育（无 ROP）相关，并且 (b) 改变的相关性与异常视网膜发育 (ROP) 相关. 利用从 <1 周大早产儿预先收集的干血斑 (DBS)，我们旨在确定 VEGF165 和 VEGF121 之间的相关性是否先于早期非增殖性 ROP (NP-ROP) 的诊断。

更新日期：2020-08-19

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