The balance of the immune microenvironment along the maternal‐fetal interface is closely related to pregnancy outcomes, with excessive inflammatory reactions leading to the occurrence of pathological pregnancy outcomes such as abortion. CaMK4 has been reported to play a significant role in autoimmune diseases through the regulation of Th17 cells. However, whether CaMK4 is associated with spontaneous abortion or the immune microenvironment along the maternal‐fetal interface remains unclear.

中文翻译：

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CaMK4 通过激活 AKT/mTOR 信号通路促进与流产相关的 Th17 细胞失衡。

母胎界面免疫微环境的平衡与妊娠结局密切相关，过度的炎症反应导致流产等病理妊娠结局的发生。据报道，CaMK4 通过调节 Th17 细胞在自身免疫性疾病中发挥重要作用。然而，CaMK4 是否与自然流产或母胎界面的免疫微环境有关仍不清楚。