INTRODUCTION We previously reported on 40 patients with Guillain-Barré syndrome (GBS) identified 1999-2005 at our center, and showed that a higher proportion had an axonal pattern, compared to Europe and North America. METHODS Retrospective chart review of 100 adult patients with GBS between 2006 and 2018 at Shamir Medical Center. RESULTS 46.8% of those with an abnormal EMG had an axonal pattern. Of the 60 patients who presented with mild disease (defined as Hughes score 1-2), walking deteriorated in 35 (58%, considering any worsening of Hughes score). 20 patients (33%) lost the ability to walk independently (Hughes score 3), 8 reached a point they could not walk (Hughes 4), and 2 needed mechanical ventilation. Ninety-four of 100 patients (94%) were treated with intravenous immunoglobulins (IVIg). Using ECG monitoring and DVT prophylaxis, IVIg-related adverse reactions were rare. CONCLUSIONS This study demonstrated a higher proportion of axonal GBS patients in Israel, compared to European and North American patients, replicating the findings in the 1999-2005 patients. Due to the progressive nature of the disease, with more than half of patients presenting with mild disease deteriorating and needing inpatient rehabilitation - we advocate initiation of treatment once a clinical diagnosis of GBS is made.

中文翻译：

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以色列吉兰-巴利综合征的电生理特征和预后：20年的单中心经验

引言 我们之前报道了 1999-2005 年在我们中心鉴定的 40 名吉兰-巴雷综合征 (GBS) 患者，结果显示与欧洲和北美相比，轴突模式的比例更高。方法 对 Shamir 医疗中心 2006 年至 2018 年间 100 名成年 GBS 患者进行回顾性图表审查。结果 46.8% 的 EMG 异常患者有轴突模式。在出现轻度疾病（定义为 Hughes 评分 1-2）的 60 名患者中，有 35 名（58%，考虑到 Hughes 评分的任何恶化）行走恶化。20 名患者 (33%) 失去独立行走能力（Hughes 评分 3），8 名患者无法行走（Hughes 4 分），2 名需要机械通气。100 名患者中有 94 名 (94%) 接受了静脉注射免疫球蛋白 (IVIg) 的治疗。使用心电图监测和 DVT 预防，IVIg 相关的不良反应很少见。结论 本研究表明，与欧洲和北美患者相比，以色列轴突 GBS 患者的比例更高，重复了 1999-2005 年患者的研究结果。由于该疾病的渐进性，超过一半的轻度疾病患者正在恶化并需要住院康复 - 我们主张一旦做出 GBS 的临床诊断就开始治疗。