The effect of Cratoxylum Formosum (CF) extract on blood pressure and changes in vascular structure and function in hypertensive rats was studied. Rats received 40 mg/kg L-NAME and treated with CF extract or captopril or captopril + CF extract (n = 8). CF extract attenuated hypertension, enhancement of nerve-mediated contractile responses, endothelial dysfunction and oxidative stress markers and raised concentrations of nitric oxide metabolites (NOx) in L-NAME treated rats. Aortic hypertrophy associated with increases in serum ACE activity, plasma angiotensin II level, and AT₁R/Akt/STAT3 protein expression in hypertensive rats were alleviated by CF extract. In hypertensive rats, captopril + CF extract administration showed greater effects on reducing blood pressure and vascular hypertrophy. Data of this study suggested that an antihypertensive effect of CF extract is linked to its antioxidant effect to enhance NO bioavailability and an inhibitory effect on RAS cascade.

研究了樟子松提取物对高血压大鼠的血压以及血管结构和功能的影响。大鼠接受40 mg / kg L-NAME，并用CF提取物或卡托普利或卡托普利+ CF提取物治疗（n = 8）。CF提取物可减轻L-NAME治疗大鼠的高血压，神经介导的收缩反应，内皮功能障碍和氧化应激标志物的升高，以及一氧化氮代谢产物（NOx）浓度的升高。与血清ACE活性，血浆血管紧张素II水平和AT ₁升高相关的主动脉肥大CF提取物可减轻高血压大鼠R / Akt / STAT3蛋白的表达。在高血压大鼠中，卡托普利+ CF提取物的给药对降低血压和血管肥大具有更大的作用。这项研究的数据表明，CF提取物的降压作用与其抗氧化作用有关，以增强NO的生物利用度和对RAS级联的抑制作用。