Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems,Journal of Advanced Research

当前位置： X-MOL 学术 › J. Adv. Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems
Journal of Advanced Research ( IF 11.4 ) Pub Date : 2020-08-01 , DOI: 10.1016/j.jare.2020.07.017
Fansu Meng ₁ , Anwarul Hasan _{2,

3} , Mohammad Mahdi Nejadi Babadaei ₄ , Pegah Hashemi Kani ₅ , Amir Jouya Talaei ₅ , Majid Sharifi ₆ , Tiange Cai ₇ , Mojtaba Falahati ₆ , Yu Cai _{8,

9,

10}

Affiliation

Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of TCM, Zhongshan, Guangdong 528400, China.
Biomedical Research Center, Qatar University, Doha 2713, Qatar.
Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, Doha 2713, Qatar.
Department of Molecular Genetics, Faculty of Biological Science, North Tehran Branch, Islamic Azad University, Tehran, Iran.
Department of Biotechnology, Faculty of Basic Science, East Tehran Branch, Islamic Azad University, Tehran, Iran.
Department of Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
College of Life Sciences, Liaoning University, Shenyang, Liaoning 110036, China.
College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China.
Cancer Institute of Jinan University, Guangzhou, Guangdong 510632, China.
International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China.

Background

Microscopic patches as quite promising platforms in transdermal drug delivery suffer from conventional injections. In other hand, a wide range of pharmacokinetics, ranging from fast oral administration to sustained drug delivery, can be implemented with the help of microneedle arrays (MNAs).

Aim of Review

Hence, in this paper, we overviewed different kinds of MNAs such as solid/coated, hollow, porous, hydrogel/swellable, and merged-tip geometry followed by introducing different types of material (silicon, glass, ceramics, dissolving and biodegradable polymers, and hydrogel) used for fabrication of MNAs. Afterwards, some conventional and brand-new simple and customizable MN mold fabrication techniques were surveyed. Polymeric MNAs have received a great deal of attention due to their potential biocompatibility and biodegradability in comparison to other materials. Therefore, we also covered different kinds of polymers such as hydrogel/swellable, dissolving and biodegradable analogues used for the development of MNAs as potential candidates in drug delivery systems (DDSs). Finally, we discussed different challenges and future perspectives in the aspect of MNAs-based drug delivery platforms.

Key Scientific Concepts of Review

This review may provide guidelines for the rational design of polymeric MNAs-based DDSs for promising programmable drug release and enhanced therapeutic effect.

中文翻译：

基于聚合物的微针阵列作为药物输送系统开发的潜在平台

背景

微型贴剂作为透皮给药的非常有前途的平台，但受到传统注射的困扰。另一方面，在微针阵列（MNA）的帮助下，可以实现从快速口服给药到持续药物递送的广泛药代动力学。

审查目的

因此，在本文中，我们概述了不同类型的 MNA，例如实心/涂层、中空、多孔、水凝胶/可膨胀和合并尖端几何形状，然后介绍了不同类型的材料（硅、玻璃、陶瓷、可溶解和可生物降解的聚合物、和水凝胶）用于制造 MNA。随后，对一些传统的和全新的简单、可定制的MN模具制造技术进行了调查。与其他材料相比，聚合物 MNA 因其潜在的生物相容性和生物降解性而受到广泛关注。因此，我们还涵盖了用于开发 MNA 的不同类型的聚合物，例如水凝胶/可溶胀、可溶解和可生物降解的类似物，作为药物输送系统 (DDS) 的潜在候选者。最后，我们讨论了基于 MNA 的药物输送平台方面的不同挑战和未来前景。