Journal of Advanced Research ( IF 6.992 ) Pub Date : 2020-08-01 , DOI: 10.1016/j.jare.2020.07.017 Fansu Meng; Anwarul Hasan; Mohammad Mahdi Nejadi Babadaei; Pegah Hashemi Kani; Amir Jouya Talaei; Majid Sharifi; Tiange Cai; Mojtaba Falahati; Yu Cai
Microscopic patches as quite promising platforms in transdermal drug delivery suffer from conventional injections. In other hand, a wide range of pharmacokinetics, ranging from fast oral administration to sustained drug delivery, can be implemented with the help of microneedle arrays (MNAs). Hence, in this paper, we overviewed different kinds of MNAs such as solid/coated, hollow, porous, hydrogel/swellable, and merged-tip geometry followed by introducing different types of material (silicon, glass, ceramics, dissolving and biodegradable polymers, and hydrogel) used for fabrication of MNAs. Afterwards, some conventional and brand-new simple and customizable MN mold fabrication technique were surveyed. Polymeric MNAs have received a great deal of attention due to their potential biocompatibility and biodegradability in comparison to other materials. Therefore, we also covered different kinds of polymers such as hydrogel/swellable, dissolving and biodegradable analogues used for the development of MNAs as potential platforms in drug delivery systems (DDSs). Finally, we discussed different challenges and future perspective in aspect of MNAs-based drug delivery platforms. This review may provide guidelines for the rational design of polymeric MNAs-based DDSs for promising programmable drug release and enhanced therapeutic effect.