Adipokines (APN) are mainly secreted by adipocytes, macrophages and various other cells, along with their role in the regulation and mediation of inflammatory responses. APN is almost exclusively synthesized by adipocytes and regulated by peroxisome proliferator-activated receptor γ (PPARγ) that is involved in the epithelial-mesenchymal transition, linked lung fibrosis. Leptin is involved in acute lung injury with a role in lung fibrogenesis. Little is known about the relationship between APN/leptin and idiopathic pulmonary fibrosis (IPF) and the few studies available in the literature used ELISA to detect these lipid mediators. Our study is also the first to measure adipokines by the new multiplex assay and for the first time were performed in bronchoalveolar lavage (BAL) from IPF patients. This preliminary study suggests that APN levels in serum could be useful for predicting the prognosis of IPF, as they are inversely correlated with DLco percentages and BMI. Moreover, this first analysis of APN in BAL from IPF patients by a new method demonstrated an inverse correlation between these levels and BMI values and a direct correlation with eosinophil percentages, both of which are negative prognostic factors of IPF.

脂肪因子(APN) 主要由脂肪细胞、巨噬细胞和各种其他细胞分泌，并在炎症反应的调节和介导中发挥作用。接入点几乎完全由脂肪细胞合成，并受过氧化物酶体增殖物激活受体 γ (PPARγ) 调节，该受体参与与肺纤维化相关的上皮间质转化。瘦素参与急性肺损伤，并在肺纤维化中起作用。关于 APN/瘦素与特发性肺纤维化 (IPF) 之间的关系知之甚少，文献中可用的少数研究使用 ELISA 检测这些脂质介质。我们的研究也是第一个通过新的多重测定测量脂肪因子的研究，并且首次在 IPF 患者的支气管肺泡灌洗 (BAL) 中进行。这项初步研究表明，血清中的 APN 水平可用于预测 IPF 的预后，因为它们与 DLco 百分比和 BMI 呈负相关。而且，