Amylin is a pancreatic hormone cosecreted along with insulin and involved in pancreatic amyloidosis and β-cell apoptosis in diabetic cats and humans. Amylin is usually elevated in early stages of type 2 diabetes but recently was found to be increased in acute and chronic pancreatitis in humans. Currently, there are little data about feline amylin propensity to fibrillate and no information on circulating levels of this hormone during feline pancreatitis. We compared 4 amylin analogues and found cat amylin to be more prone to amyloid fibrillation than human amylin, the triple-proline analogue pramlintide and rat amylin. We also measured plasma amylin levels in healthy lean cats, diabetic cats, and cats with pancreatitis. Plasma amylin was higher in diabetic cats compared with healthy lean cats (P < 0.001). Interestingly, amylin levels during pancreatitis were higher than those of both lean cats (P < 0.0001) and diabetic cats without pancreatitis (P < 0.005). These data support evidence of feline amylin being more prone to aggregation than human amylin in vitro, which may influence diabetes mellitus progression and β-cell failure in vivo. Furthermore, our data show an increase in amylin levels during feline pancreatitis and the need for future research on the role of this hormone in the pathogenesis of pancreatic inflammation associated to feline diabetes mellitus.

胰淀素是一种与胰岛素共同分泌的胰腺激素，参与糖尿病猫和人类的胰腺淀粉样变性和 β 细胞凋亡。胰淀素通常在 2 型糖尿病早期升高，但最近发现在人类急性和慢性胰腺炎中升高。目前，关于猫胰岛淀粉样多肽纤维化倾向的数据很少，也没有关于猫胰腺炎期间这种激素的循环水平的信息。我们比较了 4 种胰淀素类似物，发现猫胰淀素比人胰淀素、三脯氨酸类似物普兰林肽和大鼠胰淀素更容易发生淀粉样蛋白纤维化。我们还测量了健康瘦猫、糖尿病猫和胰腺炎猫的血浆胰淀素水平。与健康瘦猫相比，糖尿病猫的血浆胰淀素水平更高（P< 0.001)。有趣的是，胰腺炎期间的胰淀素水平高于瘦猫（P < 0.0001）和没有胰腺炎的糖尿病猫（P < 0.005）。这些数据支持猫胰淀素在体外比人胰淀素更容易聚集的证据，这可能会影响体内糖尿病的进展和 β 细胞衰竭。此外，我们的数据显示猫胰腺炎期间胰淀素水平升高，并且需要进一步研究这种激素在与猫糖尿病相关的胰腺炎症发病机制中的作用。