Breast cancer is a refractory malignancy particularly in women, with an accruing morbidity and mortality worldwide. The purpose of this study was to evaluate the efficacy of laser-induced near-infrared (NIR) PFP/Gd-DTPA/ICG@PLGA NPs (PGINPs) in US/MR imaging and regimen for breast cancer; gadolinium-DTPA (Gd-DTPA), perfluoropentane (PFP) and indocyanine green (ICG) were wrapped in the poly (lactic-co-glycolic) acid (PLGA) shell membrane via a double emulsion approach. In this study, under the irradiation of NIR laser, the ICG enriched in the cancerous tissue not only converted optic energy into thermal energy to rapidly heat up the cancer focus but also convert O₂ to singlet oxygen (¹O₂), which can effectively destroy the cancer tissues through photothermal therapy (PTT) and photodynamic therapy (PDT). Meanwhile, the thermal energy thus generated could promote the gasification of PFP to enable visualization of cancer tissues under US imaging. Gd-DTPA in combination with US imaging can also significantly enhance MR imaging to provide US/MR dual-modal imaging. This study proves the efficacy of NIR-inspired multifunctional nano-system PGINPs to potentiate US/MR imaging and regimen for breast cancer.

乳腺癌是一种难治性恶性肿瘤，尤其是在女性中，其发病率和死亡率在全世界范围内都有所上升。这项研究的目的是评估激光诱导的近红外（NIR）PFP / Gd-DTPA / ICG @ PLGA NP（PGINP）在US / MR成像和乳腺癌治疗方案中的功效；a-DTPA（Gd-DTPA），全氟戊烷（PFP）和吲哚菁绿（ICG）通过双乳液方法包裹在聚乳酸-乙醇酸共聚物（PLGA）壳膜中。在这项研究中，在NIR激光的照射下，富集在癌组织中的ICG不仅将光能转化为热能以快速加热癌症灶，还将O ₂转化为单线态氧（¹ O ₂），可以通过光热疗法（PTT）和光动力疗法（PDT）有效地破坏癌症组织。同时，由此产生的热能可以促进PFP的气化，从而能够在US成像下可视化癌组织。Gd-DTPA与US成像相结合还可显着增强MR成像，从而提供US / MR双模态成像。这项研究证明了受NIR启发的多功能纳米系统PGINPs增强乳腺癌的US / MR成像和治疗方案的功效。