OBJECTIVE To assess outcomes at 12 and 24 months following participation in a multidisciplinary cardiac rehabilitation program plus usual care compared with usual care alone for patients treated for atrial fibrillation with catheter ablation. DESIGN Long-term follow-up on the randomized CopenHeartRFA trial. STETTING Patients were enrolled and outcome assessed at the hospital and the intervention were carried out at the hospital or at local rehabilitation centers. PARTICIPANTS Patients treated for atrial fibrillation with catheter ablation included in the CopenHeartRFA trial. INTERVENTIONS A six months cardiac rehabilitation program consisting of physical exercise and psycho-educational consultations plus usual care or usual care alone. MAIN OUTCOME MEASURES Physical capacity was measured by peak oxygen uptake (VO2 peak) at 12 months and patient-reported outcomes on perceived health, anxiety and depression were collected at by validated questionnaires at 12 and 24 months. Information on hospital admissions and mortality was collected through national registers up to 24 months. RESULTS Mean VO2 peak was higher at 12 months in the cardiac rehabilitation group (cardiac rehabilitation group: 25.82 ml/kg/min vs. usual care group, 22.43 ml/kg/min, p=0.003). A lower; proportion of patients had high levels of anxiety at 24 months in the cardiac rehabilitation group; compared to usual care (12% vs 24%, p=0.004). There was no difference in mortality or hospital; admissions at 24 months between groups. CONCLUSIONS This long-term follow-up of a comprehensive multidisciplinary cardiac rehabilitation program for patients treated for atrial fibrillation with catheter ablation found sustained improvements with respect to physical capacity and anxiety compared to usual care but no difference on mortality or hospital admission.

中文翻译：

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接受消融治疗的房颤患者的心脏康复具有长期影响：随机 CopenHeartRFA 试验的 12 和 24 个月随访结果

目的 评估心房颤动导管消融患者在参与多学科心脏康复计划加常规护理后 12 个月和 24 个月时的结局与单独常规护理相比较。设计 随机 CopenHeartRFA 试验的长期随访。STETTING 患者入组并在医院评估结果，干预在医院或当地康复中心进行。参与者 CopenHeartRFA 试验中包括接受导管消融治疗的心房颤动患者。干预 为期六个月的心脏康复计划，包括体育锻炼和心理教育咨询以及常规护理或常规护理。主要结局指标 体力测量通过 12 个月的峰值摄氧量（VO2 峰值）进行测量，并在 12 个月和 24 个月时通过经过验证的问卷收集患者报告的关于感知健康、焦虑和抑郁的结果。通过长达 24 个月的国家登记册收集有关住院和死亡率的信息。结果 心脏康复组的平均 VO2 峰值在 12 个月时更高（心脏康复组：25.82 ml/kg/min 与常规护理组，22.43 ml/kg/min，p=0.003）。较低; 心脏康复组患者在 24 个月时出现高度焦虑的比例；与常规护理相比（12% 对 24%，p=0.004）。死亡率或住院率没有差异；组间 24 个月的入院。