Abstract

A novel route for the preparation of 2H-1,4- benzoxazin-3(4H)one and 1,5 benzoxazepinones by intramolecular cyclization of N-hydroxy 2-phenoxyacetamide and N-hydroxy -3 phenoxypropanamide using PPA and Lewis acid has been discussed.

Graphical abstract

Preparation of 2H-1,4- benzoxazin-3(4H)one and 1,5 benzoxazepinones by electrophilic aromatic substitution from N-hydroxy 2-phenoxyacetamide and N-hydroxy -3 phenoxypropanamide and their acetyl and benzoyl derivatives using PPA and Lewis acids.

中文翻译：

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N-羟基-2-苯氧基乙酰胺和3-苯氧基丙酰胺的分子内环化

摘要

讨论了通过PPA和路易斯酸对N-羟基2-苯氧基乙酰胺和N-羟基-3苯氧基丙酰胺进行分子内环化反应制备2H-1,4-苯并恶嗪-3（4H）酮和1,5苯并x庚酮的新途径。

图形概要

使用PPA和路易斯酸，通过N-羟基2-苯氧基乙酰胺和N-羟基-3苯氧基丙酰胺及其乙酰基和苯甲酰基衍生物的亲电芳族取代反应制备2H-1,4-苯并恶嗪-3（4H）酮和1,5-苯并a嗪酮。