We studied the effect of Semax on the state of intestinal microbiota in rats subjected to restraint stress. Semax was injected to Wistar male rats intraperitoneally in doses of 5, 50, 150, 450 μg/kg 12-15 min before modelling chronic restraint stress. It was found that stress exposure reduced the number of obligate bacteria in the colon microbiota, but increased the content of opportunistic microorganisms. Semax in doses of 50 and 150 μg/kg prevented the stress-induced changes in the composition of colon microbiota. The observed effects of Semax might be mediated by the central neurotropic effects as well as by binding to peripheral melanocortin receptors of the intestine.

中文翻译：

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抑制应激条件下ACTH(4-7)-PGP肽(Semax)处理大鼠结肠微生物群的组成

我们研究了 Semax 对受到束缚应激的大鼠肠道微生物群状态的影响。在建立慢性束缚应激模型前 12-15 分钟，将 Semax 以 5、50、150、450 μg/kg 的剂量腹膜内注射到 Wistar 雄性大鼠。研究发现，压力暴露减少了结肠微生物群中专性细菌的数量，但增加了机会性微生物的含量。50 和 150 μg/kg 剂量的 Semax 可防止应激引起的结肠微生物群组成的变化。观察到的 Semax 的作用可能是由中枢神经作用以及与肠道外周黑皮质素受体的结合介导的。