Sulfamethoxazole (SMZ) is a kind of sulfonamides antibiotic, which is widely used in human life. This study investigated the effects of SMZ on physiological and biochemical indexes of Chlorella vulgaris (C. vulgaris) and Microcystis aeruginosa (M. aeruginosa) for 35-day. The results showed that SMZ inhibited the growth and Chl-a content of C. vulgaris and M. aeruginosa, and growth inhibition rate was 8.06%–95.86%, Chl-a content decreased 2.44%–98.04%. SMZ resulting in increased SOD and CAT activity and destroyed the dynamic balance of antioxidant system. In addition, SMZ increased the content of malondialdehyde (MDA) in algae, destroyed the cell membrane to a certain extent, which was 1.8–7.3 folds higher than the control group. High concentration of SMZ can make algae cells exceed the limit of cell antioxidant capacity. Coupled with the serious damage of cell membrane, algae cells begin to appear a large number of death phenomenon.

磺胺甲恶唑（SMZ）是一种磺胺类抗生素，在人类生活中被广泛使用。这项研究调查了SMZ对小球藻（C. vulgaris）和铜绿微囊藻（M. aeruginosa）生理和生化指标的影响，为期35天。结果表明，SMZ抑制了寻常小球藻和铜绿假单胞菌的生长和Chl- a含量，生长抑制率为8.06％–95.86％，Chl- a含量下降2.44％–98.04％。SMZ导致SOD和CAT活性增加，并破坏了抗氧化剂系统的动态平衡。此外，SMZ增加了藻类中丙二醛（MDA）的含量，在一定程度上破坏了细胞膜，比对照组高1.8-7.3倍。高浓度的SMZ可使藻类细胞超过细胞抗氧化能力的极限。加上细胞膜的严重破坏，藻类细胞开始出现大量死亡现象。