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GC × GC-MS analysis and hypolipidemic effects of polyphenol extracts from Shanxi-aged vinegar in rats under a high fat diet.
Food & Function ( IF 5.1 ) Pub Date : 2020-07-31 , DOI: 10.1039/d0fo01266a Peng Du 1 , Junhan Zhou 1 , Li Zhang 1 , Jiaojiao Zhang 1 , Nan Li 1 , Chaoya Zhao 2 , Linna Tu 1 , Yu Zheng 1 , Ting Xia 1 , Jianmei Luo 1 , Jia Song 1 , Min Wang 1
Food & Function ( IF 5.1 ) Pub Date : 2020-07-31 , DOI: 10.1039/d0fo01266a Peng Du 1 , Junhan Zhou 1 , Li Zhang 1 , Jiaojiao Zhang 1 , Nan Li 1 , Chaoya Zhao 2 , Linna Tu 1 , Yu Zheng 1 , Ting Xia 1 , Jianmei Luo 1 , Jia Song 1 , Min Wang 1
Affiliation
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Oxidative stress, inflammation and gut microbiota disorders can be induced by long-term high-fat diets (HFD). In order to confirm that polyphenols can improve these symptoms, polyphenols from Shanxi-aged vinegar (SAVEP) were extracted, and the components were detected by Comprehensive two-dimensional gas chromatography mass spectrometry (GC × GC-MS). 41 polyphenols include 18 phenolic acids and 17 polyphenols, which have not been reported. The mechanism of SAVEP on oxidative stress and inflammatory stress induced by HFD in rats and its regulating effect on intestinal flora disorder were studied. The results showed that SAVEP could significantly improve the lipid, inflammatory stress and oxidative stress related indicators compared with the Model group (“Model” refers to the group that successfully constructed a hyperlipidemia model by feeding HFD without any drugs or SAVEP in subsequent experiments.). In addition, SAVEP decreased the Firmicutes/Bacteroidetes ratio compared with the Model group, and elevated the relative abundance of beneficial bacteria. Conclusively, SAVEP can alleviate the oxidative stress and inflammatory stress caused by HFD, improving intestinal microbial disorders. The Spearman's correlation analysis revealed that Desulfovibrio, Lactobacillus and Akkermansia were correlated negatively with all of the inflammatory indicators, whereas Ruminococcus was the opposite. These results suggest that SAVEP may be a novel strategy against oxidative stress and inflammation, restoring the normal microbial community ecology of the gut and the treatment of metabolic syndromes.
中文翻译：
高脂饮食大鼠山西陈醋多酚提取物的GC×GC-MS分析和降血脂作用。
长期高脂饮食（HFD）可以诱发氧化应激，炎症和肠道菌群失调。为了确定多酚可以改善这些症状，从山西陈醋中提取多酚（SAVEP），并通过综合二维气相色谱质谱法（GC×GC-MS）检测其成分。41种多酚包括18种酚酸和17种多酚，尚未见报道。研究了SAVEP对HFD诱导的大鼠氧化应激和炎症应激的作用机制及其对肠道菌群失调的调节作用。结果表明，SAVEP可以显着改善血脂，与模型组相比，炎症应激和氧化应激相关的指标（“模型”是指在随后的实验中通过喂食无任何药物或SAVEP的HFD成功构建高脂血症模型的组。）此外，SAVEP降低了与模型组相比，硬菌/拟杆菌比率提高了有益细菌的相对丰度。最终，SAVEP可以缓解由HFD引起的氧化应激和炎症应激，改善肠道微生物疾病。Spearman的相关性分析显示，脱硫弧菌，乳杆菌和阿克曼病与所有炎症指标呈负相关，而Ruminococcus相反。这些结果表明，SAVEP可能是抵抗氧化应激和炎症，恢复肠道正常微生物群落生态和治疗代谢综合征的一种新策略。
更新日期：2020-09-23
中文翻译：
高脂饮食大鼠山西陈醋多酚提取物的GC×GC-MS分析和降血脂作用。
长期高脂饮食（HFD）可以诱发氧化应激，炎症和肠道菌群失调。为了确定多酚可以改善这些症状，从山西陈醋中提取多酚（SAVEP），并通过综合二维气相色谱质谱法（GC×GC-MS）检测其成分。41种多酚包括18种酚酸和17种多酚，尚未见报道。研究了SAVEP对HFD诱导的大鼠氧化应激和炎症应激的作用机制及其对肠道菌群失调的调节作用。结果表明，SAVEP可以显着改善血脂，与模型组相比，炎症应激和氧化应激相关的指标（“模型”是指在随后的实验中通过喂食无任何药物或SAVEP的HFD成功构建高脂血症模型的组。）此外，SAVEP降低了与模型组相比，硬菌/拟杆菌比率提高了有益细菌的相对丰度。最终，SAVEP可以缓解由HFD引起的氧化应激和炎症应激，改善肠道微生物疾病。Spearman的相关性分析显示，脱硫弧菌，乳杆菌和阿克曼病与所有炎症指标呈负相关，而Ruminococcus相反。这些结果表明，SAVEP可能是抵抗氧化应激和炎症，恢复肠道正常微生物群落生态和治疗代谢综合征的一种新策略。
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