Polydopamine free radical scavengers.,Biomaterials Science

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Polydopamine free radical scavengers.
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-07-31 , DOI: 10.1039/d0bm01070g
Junfei Hu ₁ , Lei Yang , Peng Yang , Shaohua Jiang , Xianhu Liu , Yiwen Li

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Polydopamine (PDA) is the most typical kind of synthetic melanin, which possesses interesting properties such as antioxidation, photoprotection, metal chelation, and energy dissipation. Over the past few years, PDA has been successfully synthesized via polymerization methods and has demonstrated excellent free radical scavenging ability. The related applications have been rapidly expanded to include sunscreens, anti-inflammatory treatment, and composite material fabrication. Despite great progress, the comprehensive mechanisms of its free radical scavenging behaviors are not fully understood. This article strives to summarize the possible mechanisms, established antioxidant regulation methods and the related biomedical applications of PDA free radical scavengers. We believe this paper can provide insight into the current PDA scavenging systems and offer inspiration towards the design of new melanin-inspired scavengers with a broad range of biomedical applications.

中文翻译：

聚多巴胺自由基清除剂。

聚多巴胺（PDA）是最典型的合成黑色素，具有令人感兴趣的特性，例如抗氧化，光保护，金属螯合和能量耗散。在过去的几年中，PDA已成功通过聚合方法，并显示出优异的自由基清除能力。相关的应用已迅速扩展到包括防晒霜，消炎治疗和复合材料制造。尽管取得了很大进展，但对其自由基清除行为的综合机制仍未完全了解。本文力求总结PDA自由基清除剂的可能机理，建立的抗氧化剂调节方法以及相关的生物医学应用。我们相信本文可以提供对当前PDA清除系统的深入了解，并为设计具有广泛生物医学应用的新型黑色素清除剂提供灵感。

更新日期：2020-09-15

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