The 2020 SARS-CoV-2 pandemic is caused by a zoonotic coronavirus transmitted to humans, similar to earlier events. Whether the other, seasonally circulating coronaviruses induce cross-reactive, potentially even cross-neutralizing antibodies to the new species in humans is unclear. The question is of particular relevance for people with immune deficiencies, as their health depends on treatment with immunoglobulin preparations that need to contain neutralizing antibodies against the pathogens in their environment. Testing 54 IVIG preparations, produced from plasma collected in Europe and the US, highly potent neutralization of a seasonal coronavirus was confirmed, yet no cross-neutralization of the new SARS-CoV-2 was seen.

中文翻译：

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2020年大流行前收集的血浆中产生的静脉内免疫球蛋白无SARS-CoV-2交叉中和作用

2020年SARS-CoV-2大流行是由传播给人类的人畜共患冠状病毒引起的，这与早期事件类似。尚不清楚其他季节性传播的冠状病毒是否会诱导针对人类新物种的交叉反应，甚至可能是交叉中和的抗体。这个问题对免疫缺陷患者特别重要，因为他们的健康取决于免疫球蛋白制剂的治疗，该制剂需要含有针对其环境中病原体的中和抗体。测试了54种IVIG制剂，这些制剂是从欧洲和美国收集的血浆中产生的，可以有效地中和季节性冠状病毒，但没有发现新SARS-CoV-2的交叉中和作用。