Decellularized Extracellular Matrix-based Bioinks for Engineering Tissue- and Organ-specific Microenvironments.,Chemical Reviews

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Decellularized Extracellular Matrix-based Bioinks for Engineering Tissue- and Organ-specific Microenvironments.
Chemical Reviews ( IF 51.4 ) Pub Date : 2020-07-31 , DOI: 10.1021/acs.chemrev.9b00808
Byoung Soo Kim _{1,

2} , Sanskrita Das ₃ , Jinah Jang _{1,

2,

3,

4,

5,

6} , Dong-Woo Cho _{2,

4,

6}

Affiliation

Biomaterials-based biofabrication methods have gained much attention in recent years. Among them, 3D cell printing is a pioneering technology to facilitate the recapitulation of unique features of complex human tissues and organs with high process flexibility and versatility. Bioinks, combinations of printable hydrogel and cells, can be utilized to create 3D cell-printed constructs. The bioactive cues of bioinks directly trigger cells to induce tissue morphogenesis. Among the various printable hydrogels, the tissue- and organ-specific decellularized extracellular matrix (dECM) can exert synergistic effects in supporting various cells at any component by facilitating specific physiological properties. In this review, we aim to discuss a new paradigm of dECM-based bioinks able to recapitulate the inherent microenvironmental niche in 3D cell-printed constructs. This review can serve as a toolbox for biomedical engineers who want to understand the beneficial characteristics of the dECM-based bioinks and a basic set of fundamental criteria for printing functional human tissues and organs.

中文翻译：

用于工程组织和器官特异性微环境的脱细胞细胞外基质生物墨水。

近年来，基于生物材料的生物制造方法备受关注。其中，3D 细胞打印是一项开创性技术，可促进复杂人体组织和器官的独特特征的重现，具有高度的工艺灵活性和多功能性。Bioinks 是可打印水凝胶和细胞的组合，可用于创建 3D 细胞打印结构。生物墨水的生物活性线索直接触发细胞诱导组织形态发生。在各种可打印的水凝胶中，组织和器官特异性脱细胞细胞外基质 (dECM) 可以通过促进特定的生理特性，在支持任何成分的各种细胞方面发挥协同作用。在这次审查中，我们的目标是讨论一种基于 dECM 的生物墨水的新范式，能够概括 3D 细胞打印结构中固有的微环境生态位。这篇综述可以作为生物医学工程师的工具箱，他们希望了解基于 dECM 的生物墨水的有益特性以及打印功能性人体组织和器官的基本标准集。

更新日期：2020-07-31

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