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Determination of Aristolochic Acids in Vegetables: Nephrotoxic and Carcinogenic Environmental Pollutants Contaminating a Broad Swath of the Food Supply and Driving Incidence of Balkan Endemic Nephropathy.
Chemical Research in Toxicology ( IF 3.7 ) Pub Date : 2020-07-31 , DOI: 10.1021/acs.chemrestox.0c00229 Chun-Kit Au , Jiayin Zhang , Chi-Kong Chan , Cui Li 1 , Guorui Liu 1 , Nikola M Pavlović 2 , Jing Yao 3 , Wan Chan
Chemical Research in Toxicology ( IF 3.7 ) Pub Date : 2020-07-31 , DOI: 10.1021/acs.chemrestox.0c00229 Chun-Kit Au , Jiayin Zhang , Chi-Kong Chan , Cui Li 1 , Guorui Liu 1 , Nikola M Pavlović 2 , Jing Yao 3 , Wan Chan
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Balkan endemic nephropathy (BEN) is a slowly progressive interstitial fibrotic disease affecting numerous people living along the Danube River in the Balkan Peninsula, of which aristolochic acids (AAs) produced naturally in Aristolochia plants are key etiological agents. However, the exposure biology of the disease remains poorly understood. Initially, the high incidence of BEN in the Balkan Peninsula was thought to occur through ingestion of bread prepared from flour made with wheat grains comingled with the seeds of Aristolochia clematitis L., an AA-containing weed that grows abundantly in the wheat fields of the affected areas. In this study, by a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method, we show for the first time that vegetables, in particular root vegetables of endemic areas, are extensively contaminated with AAs taken up through root absorption from the AA-tainted soil. Furthermore, we found a pH dependence of the n-octanol/water partition coefficient (Kow) of AAs, which resulted in a dramatically higher hydrophobicity-driven plant uptake efficiency of AAs into food crops in endemic areas, characterized by higher acidity levels, compared to non-endemic areas. We believe the results of this study have significantly unraveled the mystery surrounding the uneven distribution of BEN incidence.
中文翻译：
蔬菜中马兜铃酸的测定：肾毒性和致癌性环境污染物污染了广泛的食品供应和巴尔干地方性肾病的发病率。
巴尔干地方性肾病（BEN）是影响多瑙河沿岸巴尔干半岛，其中马兜铃酸（AAS）产生的自然生活中的许多人缓慢渐进的间质性纤维化疾病马兜铃植物是关键的病原。然而，对该疾病的暴露生物学仍然知之甚少。最初，BEN在巴尔干半岛的高发病率被认为通过由面粉制成的面包摄入与种子comingled麦谷物制成的发生铁线莲状马兜铃L.，一种含 AA 的杂草，在受影响地区的麦田中大量生长。在这项研究中，通过液相色谱-串联质谱 (LC-MS/MS) 方法，我们首次表明蔬菜，特别是流行地区的根茎类蔬菜，被根部吸收的 AA 广泛污染。 AA 污染的土壤。此外，我们发现所述的pH依赖性Ñ辛醇/水分配系数（ķ流) 的氨基酸，这导致在地方性地区的粮食作物中疏水性驱动的植物吸收氨基酸的效率显着提高，与非地方性地区相比，酸度水平更高。我们相信这项研究的结果已经显着解开了围绕 BEN 发生率分布不均的谜团。
更新日期：2020-09-21
中文翻译：
蔬菜中马兜铃酸的测定：肾毒性和致癌性环境污染物污染了广泛的食品供应和巴尔干地方性肾病的发病率。
巴尔干地方性肾病（BEN）是影响多瑙河沿岸巴尔干半岛，其中马兜铃酸（AAS）产生的自然生活中的许多人缓慢渐进的间质性纤维化疾病马兜铃植物是关键的病原。然而，对该疾病的暴露生物学仍然知之甚少。最初，BEN在巴尔干半岛的高发病率被认为通过由面粉制成的面包摄入与种子comingled麦谷物制成的发生铁线莲状马兜铃L.，一种含 AA 的杂草，在受影响地区的麦田中大量生长。在这项研究中，通过液相色谱-串联质谱 (LC-MS/MS) 方法，我们首次表明蔬菜，特别是流行地区的根茎类蔬菜，被根部吸收的 AA 广泛污染。 AA 污染的土壤。此外，我们发现所述的pH依赖性Ñ辛醇/水分配系数（ķ流) 的氨基酸，这导致在地方性地区的粮食作物中疏水性驱动的植物吸收氨基酸的效率显着提高，与非地方性地区相比，酸度水平更高。我们相信这项研究的结果已经显着解开了围绕 BEN 发生率分布不均的谜团。
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