Coevolution of Atomic Resolution and Whole-Brain Imaging for Tau Neurofibrillary Tangles.,ACS Chemical Neuroscience

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Coevolution of Atomic Resolution and Whole-Brain Imaging for Tau Neurofibrillary Tangles.
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2020-07-30 , DOI: 10.1021/acschemneuro.0c00426
Raeann M Dalton ₁ , Hema S Krishnan _{1,

2} , Victoria S Parker _{1,

2} , Mary C Catanese _{1,

2} , Jacob M Hooker _{1,

2}

Affiliation

Neurofibrillary tangle (NFT) imaging methods at the distinct scales of atomic and whole-brain resolutions have coevolved rapidly. Linking these two areas of research provides insight into how and why certain tau radiotracers, using positron emission tomography (PET), bind selectively to certain morphological forms of the NFT fibril. In this Review, a brief history and background for each research area is presented leading to a summary of the current state of knowledge, with a synopsis of PET NFT radiotracers and an outlook for near-term research efforts. The continued integration of information provided at the level of each of these scales of resolution will catalyze the next generation of clinical imaging technique development and enhance our interpretations of them.

中文翻译：

Tau神经原纤维缠结的原子分辨率和全脑成像的共同进化。

原子和全脑分辨率的不同尺度的神经原纤维缠结（NFT）成像方法发展迅速。将这两个研究领域联系起来，就可以洞察某些使用正电子发射断层扫描（PET）的tau放射性示踪剂如何选择性地结合到NFT原纤维的某些形态上。在本综述中，简要介绍了每个研究领域的历史和背景，从而总结了当前的知识状态，并简要介绍了PET NFT放射性示踪剂，并展望了近期的研究工作。在每个分辨率级别上提供的信息的持续集成将催化下一代临床成像技术的发展，并增强我们对它们的理解。

更新日期：2020-09-02

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