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Ultrasound-Responsive Carriers for Therapeutic Applications
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-07-30 , DOI: 10.1021/acsbiomaterials.9b01979 Rajeet Chandan 1 , Sourabh Mehta 1, 2 , Rinti Banerjee 1
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-07-30 , DOI: 10.1021/acsbiomaterials.9b01979 Rajeet Chandan 1 , Sourabh Mehta 1, 2 , Rinti Banerjee 1
Affiliation
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Ultrasound (US)-responsive carriers have emerged as promising theranostic candidates because of their ability to enhance US-contrast, promote image-guided drug delivery, cause on-demand pulsatile release of drugs in response to ultrasound stimuli, as well as to enhance the permeability of physiological barriers such as the stratum corneum, the vascular endothelium, and the blood-brain barrier (BBB). US-responsive carriers include microbubbles MBs, liposomes, droplets, hydrogels, and nanobubble–nanoparticle complexes and have been explored for cavitation-mediated US-responsive drug delivery. Recently, a transient increase in the permeability of the BBB by microbubble (MB)-assisted low-frequency US has shown promise in enhancing the delivery of therapeutic agents in the case of neurological disorders. Further, the periodic mechanical stimulus generated by US-responsive MBs have also been explored in tissue engineering and has directly influenced the differentiation of mesenchymal stem cells into cartilage. This Review discusses the various types of US-responsive carriers and explores their emerging roles in therapeutics ranging from drug delivery to tissue engineering.
中文翻译：
用于治疗应用的超声响应载体
超声（US）响应载体已成为有希望的治疗学候选者，因为它们能够增强US对比度，促进图像引导的药物输送，响应超声刺激按需脉冲释放药物以及增强超声治疗能力。生理屏障如角质层，血管内皮和血脑屏障（BBB）的渗透性。对美国有反应的载体包括微泡MB，脂质体，小滴，水凝胶和纳米泡－纳米颗粒复合物，并已针对空化介导的对美国有反应的药物进行了研究。最近，通过微泡（MB）辅助的低频超声在血脑屏障通透性方面的短暂增加已显示出在神经系统疾病的情况下增强治疗剂输送的希望。进一步，在组织工程中也已经探索了由US响应性MB产生的周期性机械刺激，并直接影响了间充质干细胞向软骨的分化。这篇评论讨论了各种类型的对美国有反应的载体，并探讨了它们在从药物递送到组织工程的治疗学中的新兴作用。
更新日期：2020-09-14
中文翻译：
用于治疗应用的超声响应载体
超声（US）响应载体已成为有希望的治疗学候选者，因为它们能够增强US对比度，促进图像引导的药物输送，响应超声刺激按需脉冲释放药物以及增强超声治疗能力。生理屏障如角质层，血管内皮和血脑屏障（BBB）的渗透性。对美国有反应的载体包括微泡MB，脂质体，小滴，水凝胶和纳米泡－纳米颗粒复合物，并已针对空化介导的对美国有反应的药物进行了研究。最近，通过微泡（MB）辅助的低频超声在血脑屏障通透性方面的短暂增加已显示出在神经系统疾病的情况下增强治疗剂输送的希望。进一步，在组织工程中也已经探索了由US响应性MB产生的周期性机械刺激，并直接影响了间充质干细胞向软骨的分化。这篇评论讨论了各种类型的对美国有反应的载体，并探讨了它们在从药物递送到组织工程的治疗学中的新兴作用。
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