ABSTRACT

A new one-pot method for the synthesis four-component of pyrazolo [4′,3′:5,6]pyrano [2,3-c]phenazin-15-yl)methanone derivatives has been developed in the presence of nano Fe₃O₄@TiO₂-SO₃H catalysts (heterogeneous acid) under microwave conditions and in a solvent-free environment at 180 W. One of the benefits of using this catalyst was its re-use in subsequent stages of its reaction without much loss in its activity, which was carried out by an external magnet and recovered. The catalyst was synthesized and characterized by XRD, EDX, TEM, FESEM, TGA-DTA, BET, VSM and AFM. The productivity of the products obtained from this protocol (MAOS) is significantly high and the shorter reaction time in the synthesis process over the reflux method. These results showed advantages for synthesis, such as mild reaction conditions, no use of toxic catalysts in the laboratory, solvent-free environment, low energy consumption and Economically Affordable.

摘要

在纳米铁的存在下，开发了一种新的一锅法合成吡唑并[4'，3'：5,6]吡喃并[2,3 - c ]吩嗪-15-基）甲酮衍生物的四组分₃ O ₄ @TiO ₂ -SO ₃H催化剂（非均相酸）在微波条件下和无溶剂的环境下在180 W下使用。使用该催化剂的好处之一是可以在反应的后续阶段重新使用，而不会损失太多活性通过外部磁铁恢复。通过XRD，EDX，TEM，FESEM，TGA-DTA，BET，VSM和AFM对催化剂进行了合成和表征。通过该方法获得的产物（MAOS）的生产率非常高，合成过程中的反应时间比回流法短。这些结果显示出合成的优势，例如温和的反应条件，实验室中不使用有毒催化剂，无溶剂的环境，低能耗和经济上可承受的。