ABSTRACT

Introduction

Vaccines and therapeutic antibodies are the most crucial components of anthrax prophylaxis (pre- and post-exposure) and treatment. The improvement in the availability and safety profile of vaccines and the therapeutic antibodies has helped immensely in reducing the worldwide burden of anthrax.

Areas covered

Current recommendations for anthrax prophylaxis and control, vaccines and therapeutic antibodies, the recent endeavors, particularly, made after 2010 toward making them safer and more efficacious along with our opinion on its future course. Primarily, PubMed and Europe PMC were searched to cover the recent developments in the above-indicated areas.

Expert opinion

Some key existing lacunae in our understanding of the working of biologicals-based anthrax-control measures, i.e., vaccines and therapeutic antibodies, should be addressed to improve their overall stability, safety profile, and efficacy. The identification of novel inhibitors targeting different key-molecules and vital-steps contributing to the overall anthrax pathophysiology could make a difference in anthrax control.

中文翻译：

---

通过疫苗和暴露后治疗预防炭疽病。

摘要

介绍

疫苗和治疗性抗体是预防炭疽（暴露前和暴露后）和治疗的最关键组成部分。疫苗和治疗性抗体的可用性和安全性方面的改善极大地帮助减轻了全球炭疽病负担。

覆盖区域

当前对炭疽的预防和控制，疫苗和治疗性抗体的建议，尤其是最近的努力，是在2010年之后提出的，旨在使其更安全，更有效，同时我们对未来的发展也提出了自己的看法。首先，对PubMed和Europe PMC进行了搜索，以涵盖上述区域的最新发展。

专家意见

在我们的工作的理解存在漏洞的一些关键生物制品为主的炭疽控制措施，即，疫苗和治疗性抗体，应当向提高他们的整体稳定性，安全性和功效。鉴定靶向不同关键分子和关键步骤的新型抑制剂对整个炭疽的病理生理有贡献，这可能会影响炭疽的控制。