The inflammatory immune response (IIR) is a physiological or excessive systemic response, induced by inflammatory immune cells according to changes in the internal and external environments. An excessive IIR is the pathological basis for the generation and development of neurological diseases. Ginkgolides are one of the important medicinal ingredients in Ginkgo biloba. Many studies have verified that ginkgolides have anti-platelet-activating, anti-apoptotic, anti-oxidative, neurotrophic, and neuroimmunomodulatory effects. Inflammatory immunomodulation is mediated by inhibition of the mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling pathways. They also inhibit the platelet-activating factor (PAF)-mediated signal transduction to attenuate the inflammatory response. Herein, we reviewed the studies on the roles of ginkgolides in inflammatory immunomodulation and suggested its potential role in novel treatments for neurological diseases.

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银杏内酯在神经系统疾病炎症免疫反应中的作用：现有文献综述

炎症免疫反应（IIR）是一种生理或过度的全身反应，由炎症免疫细胞根据内外环境的变化而诱导。过度的IIR是神经系统疾病产生和发展的病理基础。银杏内酯是银杏的重要药用成分之一。许多研究证实银杏内酯具有抗血小板活化、抗凋亡、抗氧化、神经营养和神经免疫调节作用。炎症免疫调节是通过抑制丝裂原活化蛋白激酶 (MAPK) 和核因子-κB (NF-κB) 信号通路介导的。它们还抑制血小板激活因子 (PAF) 介导的信号转导以减弱炎症反应。在此处，